Literature DB >> 921403

Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN.

T U Järbe, B G Henriksson, G C Ohlin.   

Abstract

Pigeons, trained to discriminate the effects of i.m. injections of delta9-tetrahydrocannabinol (delta9-THC, 0.25 mg/kg) from the effects of the vehicle in a drug discrimination paradigm, were tested for generalization with the isomeric delta8-THC, cannabidiol (CBD) and cannabinol (CBN). When given in sufficient doses, delta8-THC and CBN were found to substitute for delta9-THC whereas CBD did not. CBD and CBN did not antagonize the stimulus effect of delta9-THC. The combination of CBN and delta9-THC rather appeared to accentuate the drug response.

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Year:  1977        PMID： 921403

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN： 0003-9780


  12 in total

1.  Discriminative effects of combinations of delta 9-tetrahydrocannabinol and pentobarbital in pigeons.

Authors:  T U Järbe; G C Ohlin
Journal:  Psychopharmacology (Berl)       Date:  1979-06-21       Impact factor: 4.530

2.  Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.

Authors:  Lance R McMahon; Brett C Ginsburg; R J Lamb
Journal:  Psychopharmacology (Berl)       Date:  2007-08-03       Impact factor: 4.530

Review 3.  Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review.

Authors:  John M McPartland; Marnie Duncan; Vincenzo Di Marzo; Roger G Pertwee
Journal:  Br J Pharmacol       Date:  2015-02       Impact factor: 8.739

4.  Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol.

Authors:  Robert E Vann; Thomas F Gamage; Jonathan A Warner; Ericka M Marshall; Nathan L Taylor; Billy R Martin; Jenny L Wiley
Journal:  Drug Alcohol Depend       Date:  2008-04-01       Impact factor: 4.492

5.  delta 9-THC as a discriminative stimulus in rats and pigeons: generalization to THC metabolites and SP-111.

Authors:  T U Järbe; D E McMillan
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

6.  The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys.

Authors:  K T Brady; R L Balster
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

Review 7.  Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg.

Authors:  Gianluigi Tanda
Journal:  Psychopharmacology (Berl)       Date:  2016-03-30       Impact factor: 4.530

8.  Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.

Authors:  Lamont Booker; Pattipati S Naidu; Raj K Razdan; Anu Mahadevan; Aron H Lichtman
Journal:  Drug Alcohol Depend       Date:  2009-08-12       Impact factor: 4.492

9.  A repeated test procedure to assess onset and duration of the cue properties of (-) delta 9-THC, (-) delta 8-THC-DMH and (+) delta 8-THC.

Authors:  T U Järbe; M D Swedberg; R Mechoulam
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Enhanced discriminative stimulus effects of Δ(9)-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys.

Authors:  Lance R McMahon
Journal:  Drug Alcohol Depend       Date:  2016-06-03       Impact factor: 4.492
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