Literature DB >> 9210688

Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole.

U Natarajan1, E Brummer, D A Stevens.   

Abstract

The effect of granulocyte colony-stimulating factor (GCSF) treatment of polymorphonuclear neutrophils (PMN) in vitro was studied with respect to their candidacidal activity. The candidacidal activity of PMN was found to be significantly increased when they were pretreated with GCSF. Fluconazole (1 microg/ml) was found to be highly fungistatic (90%) for Candida albicans Sh27 and collaborated with PMN for significantly increased killing. Collaborative killing by PMN significantly increased when they were treated with GCSF before and after fungal exposure. The enhancing activities of GCSF required optimization of the GCSF dose and were thus inoculum and strain dependent.

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Year:  1997        PMID： 9210688      PMCID： PMC163962     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  High-frequency switching in Candida strains isolated from vaginitis patients.

Authors:  D R Soll; C J Langtimm; J McDowell; J Hicks; R Galask
Journal:  J Clin Microbiol       Date:  1987-09       Impact factor: 5.948

2.  Stimulation with cytokines enhances penetration of azithromycin into human macrophages.

Authors:  L E Bermudez; C Inderlied; L S Young
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191

3.  Synergy of human neutrophils with fluconazole in killing Candida species.

Authors:  E Brummer; D A Stevens
Journal:  Mycopathologia       Date:  1996       Impact factor: 2.574

4.  Efficacy of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with AIDS.

Authors:  S Kimura; J Matsuda; S Ikematsu; K Miyazono; A Ito; T Nakahata; M Minamitani; K Shimada; Y Shiokawa; F Takaku
Journal:  AIDS       Date:  1990-12       Impact factor: 4.177

5.  Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils.

Authors:  E Roilides; T J Walsh; P A Pizzo; M Rubin
Journal:  J Infect Dis       Date:  1991-03       Impact factor: 5.226

6.  Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans: augmentation by granulocyte colony-stimulating factor and interferon-gamma.

Authors:  E Roilides; K Uhlig; D Venzon; P A Pizzo; T J Walsh
Journal:  J Infect Dis       Date:  1992-09       Impact factor: 5.226

7.  Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts.

Authors:  R A Fromtling; J N Galgiani; M A Pfaller; A Espinel-Ingroff; K F Bartizal; M S Bartlett; B A Body; C Frey; G Hall; G D Roberts
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

8.  Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents.

Authors:  O Shimokawa; H Nakayama
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

9.  Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy.

Authors:  G Morstyn; L Campbell; L M Souza; N K Alton; J Keech; M Green; W Sheridan; D Metcalf; R Fox
Journal:  Lancet       Date:  1988-03-26       Impact factor: 79.321

10.  The effect of recombinant human colony-stimulating factors on hematopoietic reconstitution following autologous bone marrow transplantation.

Authors:  W P Peters
Journal:  Semin Hematol       Date:  1989-04       Impact factor: 3.851
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  4 in total

1.  Immunization with the Candida albicans membrane fraction and in combination with fluconazole protects against systemic fungal infections.

Authors:  S Mizutani; M Endo; T Ino-Ue; M Kurasawa; Y Uno; H Saito; I Kato; K Takesako
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

2.  Activity of voriconazole, a new triazole, combined with neutrophils or monocytes against Candida albicans: effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.

Authors:  S Vora; N Purimetla; E Brummer; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

Review 3.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

Review 4.  Oral manifestations in HIV infection: fungal and bacterial infections, Kaposi's sarcoma.

Authors:  Peter A Reichart
Journal:  Med Microbiol Immunol       Date:  2003-03-05       Impact factor: 3.402
  4 in total

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