| Literature DB >> 9210288 |
K Danel1, C Nielsen, E B Pedersen.
Abstract
5-Ethyl-6-(1-naphthylmethyl)uracil and 5-ethyl-6-(1-naphthylmethyl)-2-thiouracil were alkylated to give, respectively. N-1 and S2, ethoxymethyl and methylthiomethyl uracil derivatives. 5-Ethyl-6-(1-naphthylmethyl)-2-thiouracil was also S2 alkylated with methyl bromoacetate. The products showed activity against HIV-1, and the N-1 alkylated derivatives were indeed highly active.Entities:
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Year: 1997 PMID： 9210288 DOI： 10.3891/acta.chem.scand.51-0426
Source DB: PubMed Journal: Acta Chem Scand ISSN： 0904-213X