Literature DB >> 9210181

A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.

M W Walker1, K E Smith, J Bard, P J Vaysse, C Gerald, S Daouti, R L Weinshank, T A Branchek.   

Abstract

We cloned and expressed the rat Y4 receptor for pancreatic polypeptide (PP). Structure-activity profiles derived from 125I-PP binding assays and [cAMP] radioimmunoassays reveal a selective receptor interaction with rat PP vs. neuropeptide Y (NPY) or peptide YY (PYY). Rat and human Y4 receptor clones share 75% amino acid identity. Based on [cAMP] radioimmunoassay, the human Y4 receptor exhibits a less selective interaction with rat PP vs. NPY or PYY and a greater dependence on N-terminal PP residues, relative to rat Y4. Differences in sequence and structure-activity profiles suggest the rat be used with caution to model human Y4 receptor function.

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Year:  1997        PMID： 9210181     DOI： 10.1016/s0196-9781(97)00070-3

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.

Authors:  Y Dumont; R Quirion
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

2.  Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.

Authors:  Veronika Mäde; Kathrin Bellmann-Sickert; Anette Kaiser; Jens Meiler; Annette G Beck-Sickinger
Journal:  ChemMedChem       Date:  2014-08-22       Impact factor: 3.466

3.  BODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes.

Authors:  Yvan Dumont; Pierrette Gaudreau; Manuela Mazzuferi; Daniel Langlois; Jean-Guy Chabot; Alain Fournier; Michele Simonato; Rémi Quirion
Journal:  Br J Pharmacol       Date:  2005-12       Impact factor: 8.739

4.  Constitutive neuropeptide Y Y(4) receptor expression in human colonic adenocarcinoma cell lines.

Authors:  H M Cox; I R Tough; D W Zandvliet; N D Holliday
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

5.  Single Cell Peptide Heterogeneity of Rat Islets of Langerhans.

Authors:  Erik T Jansson; Troy J Comi; Stanislav S Rubakhin; Jonathan V Sweedler
Journal:  ACS Chem Biol       Date:  2016-07-29       Impact factor: 5.100

6.  NPY receptor subtype in the rabbit isolated ileum.

Authors:  M Félétou; J P Nicolas; M Rodriguez; P Beauverger; J P Galizzi; J A Boutin; J Duhault
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

7.  Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice.

Authors:  R O Tasan; S Lin; A Hetzenauer; N Singewald; H Herzog; G Sperk
Journal:  Neuroscience       Date:  2008-12-09       Impact factor: 3.590

8.  Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.

Authors:  Xavier Pedragosa-Badia; Gregory R Sliwoski; Elizabeth Dong Nguyen; Diana Lindner; Jan Stichel; Kristian W Kaufmann; Jens Meiler; Annette G Beck-Sickinger
Journal:  J Biol Chem       Date:  2013-12-27       Impact factor: 5.157

9.  Different regulation of atrial ANP release through neuropeptide Y2 and Y4 receptors.

Authors:  Feng Lian Piao; Kuichang Yuan; Guang Yi Bai; Jeong Hee Han; Woo Hyun Park; Suhn Hee Kim
Journal:  J Korean Med Sci       Date:  2008-12-24       Impact factor: 2.153
  9 in total

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