Literature DB >> 9209660

Elective surgery for gastrointestinal tumours in the elderly.

R A Audisio1, P Veronesi, L Ferrario, C Cipolla, B Andreoni, M Aapro.   

Abstract

The geriatric population is expanding and clinical decision-making is often complicated by the effects of ageing. Age should not be the only parameter considered when addressing medical problems. Elderly subjects have been denied surgery because of their presumed higher mortality and morbidity. The present review summarises the physiology of the aged and discusses operative risks, mortality and morbidity rates as well as therapeutic results for the different gastrointestinal sites when affected by cancer. Reports on surgical treatments are revisited and compared to the same procedures delivered to younger patients in the context of the ethical issue of offering the best care to every patient. Elective operations by surgical oncologists are found to be safe with the exception of major liver resections. Complication rates and mean hospital stay do not differ between the two age groups provided the procedure is conducted with the best-known technique in expert hands. A drop in operative morbidity has occurred in the past three decades. Several investigators have emphasised the marked increase in morbidity and mortality experienced by elderly patients when undergoing emergency procedures. Associated diseases have to be properly assessed, as the elderly have a frail physiological balance with a reduced capacity for recovery from traumatic events including major surgical procedures. Careful preoperative evaluation, intraoperative conduct and postoperative care are presently achieved in almost every major hospital. Good clinical practice is based on the balance between probability of cure and toxic effects. Treatment of the elderly should no longer be based on untested beliefs and personal opinions. The elderly should be accrued for prospective clinical evaluation and should not be denied optimal surgical treatment.

Entities:  

Mesh:

Year:  1997        PMID: 9209660     DOI: 10.1023/a:1008294921269

Source DB:  PubMed          Journal:  Ann Oncol        ISSN: 0923-7534            Impact factor:   32.976


  12 in total

1.  Geriatric Assessment, Not ASA Physical Status, Is Associated With 6-Month Postoperative Survival in Patients With Cancer Aged ≥75 Years.

Authors:  Armin Shahrokni; Bella Marie Vishnevsky; Brian Jang; Saman Sarraf; Koshy Alexander; Soo Jung Kim; Robert Downey; Anoushka Afonso; Beatriz Korc-Grodzicki
Journal:  J Natl Compr Canc Netw       Date:  2019-06-01       Impact factor: 11.908

2.  The impact of age on outcome after surgery for colorectal adenocarcinoma.

Authors:  A L Widdison; S Wienand Barnett; N Betambeau
Journal:  Ann R Coll Surg Engl       Date:  2011-09       Impact factor: 1.891

Review 3.  Risk Factors for Adverse Outcome for Elderly Patients undergoing Curative Oncological Resection for Gastrointestinal Malignancies.

Authors:  Yukai K Lim; Christopher Jackson; Emilia L Dauway; Konrad Klaus Richter
Journal:  Visc Med       Date:  2017-08-10

4.  Anti-EGFR (cetuximab) combined with irinotecan for treatment of elderly patients with metastatic colorectal cancer (mCRC).

Authors:  S Abdelwahab; A Azmy; H Abdel-Aziz; H Salim; A Mahmoud
Journal:  J Cancer Res Clin Oncol       Date:  2012-04-22       Impact factor: 4.553

5.  The impact of the risk factor "age" on the early postoperative results of surgery for colorectal carcinoma and its significance for perioperative management.

Authors:  Frank Marusch; Andreas Koch; Uwe Schmidt; Ralf Steinert; Torsten Ueberrueck; Reinhard Bittner; Eugen Berg; Rainer Engemann; Klaus Gellert; Rainer Arbogast; Thomas Körner; Ferdinand Köckerling; Ingo Gastinger; Hans Lippert
Journal:  World J Surg       Date:  2005-08       Impact factor: 3.352

6.  Effects of a perioperative geriatric intervention for older adults with Cancer: A randomized clinical trial.

Authors:  Ryan D Nipp; Carolyn L Qian; Helen P Knight; Cristina R Ferrone; Hiroko Kunitake; Carlos Fernandez-Del Castillo; Michael Lanuti; Motaz Qadan; Rocco Ricciardi; Keith D Lillemoe; Brandon Temel; Ardeshir Z Hashmi; Erin Scott; Erin Stevens; Grant R Williams; Zhi Ven Fong; Terrence A O'Malley; Esteban Franco-Garcia; Nora K Horick; Vicki A Jackson; Joseph A Greer; Areej El-Jawahri; Jennifer S Temel
Journal:  J Geriatr Oncol       Date:  2022-01-21       Impact factor: 3.929

7.  The recommended treatment strategy for locally advanced gastric cancer in elderly patients aged 75 years and older: a Surveillance, Epidemiology, and End Results database analysis.

Authors:  Kai-Tai Liu; Jue-Feng Wan; Gen-Hua Yu; Yan-Ping Bei; Xue Chen; Miao-Zhen Lu
Journal:  J Cancer Res Clin Oncol       Date:  2016-10-18       Impact factor: 4.553

Review 8.  Treatment of colorectal cancer in older patients.

Authors:  Riccardo A Audisio; Demetris Papamichael
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-10-09       Impact factor: 46.802

9.  Predictors of postoperative complications in elderly and oldest old patients with gastric cancer.

Authors:  Takehiro Takama; Keiichi Okano; Akihiro Kondo; Shintaro Akamoto; Masao Fujiwara; Hisashi Usuki; Yasuyuki Suzuki
Journal:  Gastric Cancer       Date:  2014-05-30       Impact factor: 7.370

Review 10.  Risk assessment for cancer surgery in elderly patients.

Authors:  Hodigere S J Ramesh; Tom Boase; Riccardo A Audisio
Journal:  Clin Interv Aging       Date:  2006       Impact factor: 4.458

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.