BACKGROUND: Intradermal skin testing is one of the most widely used procedures in the diagnosis of hypersensitivity diseases in vivo. It is critical to perform the test accurately and expediently. Yet, there are few articles describing its detailed technique or proficiency available. OBJECTIVES: To identify the better method for intradermal testing between the bevel-up and bevel-down techniques. METHODS: Three inexperienced testers performed intradermal injections using both methods. Four sets of paired trails each consisting of ten injections were applied randomly, alternating between the same volunteer subject's contralateral arms. Duration to complete ten injections was measured. Numbers of injection sites that bled, that squirted into the air, and failed to form a bleb were counted. The overall comfort level was determined. RESULTS: The time to complete the injections by bevel-up and by bevel-down methods were 165.5 +/- 31.3 and 152.5 +/- 27.4 seconds, respectively (P < .015). The number of injection sites that bled was higher in the bevel-up method, particularily on trial one (P < .001). Completion rate of successful bleb formation in bevel-down was 27.3 as compared with 23.3 in bevel-up method (P = .013). The comfort level was higher with the bevel-down than the bevel-up method (P = .0001). CONCLUSION: The bevel-down method of intradermal testing is superior to the bevel-up method.
RCT Entities:
BACKGROUND: Intradermal skin testing is one of the most widely used procedures in the diagnosis of hypersensitivity diseases in vivo. It is critical to perform the test accurately and expediently. Yet, there are few articles describing its detailed technique or proficiency available. OBJECTIVES: To identify the better method for intradermal testing between the bevel-up and bevel-down techniques. METHODS: Three inexperienced testers performed intradermal injections using both methods. Four sets of paired trails each consisting of ten injections were applied randomly, alternating between the same volunteer subject's contralateral arms. Duration to complete ten injections was measured. Numbers of injection sites that bled, that squirted into the air, and failed to form a bleb were counted. The overall comfort level was determined. RESULTS: The time to complete the injections by bevel-up and by bevel-down methods were 165.5 +/- 31.3 and 152.5 +/- 27.4 seconds, respectively (P < .015). The number of injection sites that bled was higher in the bevel-up method, particularily on trial one (P < .001). Completion rate of successful bleb formation in bevel-down was 27.3 as compared with 23.3 in bevel-up method (P = .013). The comfort level was higher with the bevel-down than the bevel-up method (P = .0001). CONCLUSION: The bevel-down method of intradermal testing is superior to the bevel-up method.
Authors: Jae-Min Song; Yeu-Chun Kim; Eunju O; Richard W Compans; Mark R Prausnitz; Sang-Moo Kang Journal: Mol Ther Date: 2012-04-17 Impact factor: 11.454
Authors: Hyo-Jick Choi; Dae-Goon Yoo; Brian J Bondy; Fu-Shi Quan; Richard W Compans; Sang-Moo Kang; Mark R Prausnitz Journal: Biomaterials Date: 2012-02-21 Impact factor: 12.479
Authors: Yeu-Chun Kim; Fu-Shi Quan; Richard W Compans; Sang-Moo Kang; Mark R Prausnitz Journal: J Control Release Date: 2009-10-17 Impact factor: 9.776
Authors: Qiyun Zhu; Vladimir G Zarnitsyn; Ling Ye; Zhiyuan Wen; Yulong Gao; Lei Pan; Ioanna Skountzou; Harvinder S Gill; Mark R Prausnitz; Chinglai Yang; Richard W Compans Journal: Proc Natl Acad Sci U S A Date: 2009-04-27 Impact factor: 11.205
Authors: Dimitrios G Koutsonanos; Maria del Pilar Martin; Vladimir G Zarnitsyn; Sean P Sullivan; Richard W Compans; Mark R Prausnitz; Ioanna Skountzou Journal: PLoS One Date: 2009-03-10 Impact factor: 3.240