Literature DB >> 9207249

Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells.

L Zhang1, B Zhao, D T Yew, J W Kusiak, G S Roth.   

Abstract

The processing of Alzheimer's amyloid precursor protein was studied by Western blotting during H2O2 induced apoptosis in cultures of human neuroblastoma cells. A new 5.5 kDa fragment putatively containing intact A beta was detected and found to be highly associated with apoptosis. The results suggest a possible vicious cycle involving H2O2, A beta and apoptosis which may contribute to the neuronal death mechanism in Alzheimer's Disease.

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Year:  1997        PMID： 9207249     DOI： 10.1006/bbrc.1997.6698

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

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