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Literature DB >> 920673

Monocyte-macrophage function in the newborn.

W L Weston, B S Carson, R M Barkin, G D Slater, R D Dustin, S K Hecht.

Abstract

Analysis of 20 human cord blood samples for monocyte-macrophage function demonstrates a selective defect in monocyte cellular chemotaxis. Monocyte bacterial phagocytosis, phagocytosis of paraffin oil particles, and bacterial killing of staphylococcus 502A were normal when compared with 30 healthy young adult controls. Impaired response of neonatal monocytes to chemotactants is an additional host defense defect that may help explain the undue susceptibility of neonates to certain infectious agents.

Entities: Chemical Species

Mesh：

Year: 1977 PMID： 920673 DOI： 10.1001/archpedi.1977.02120240059011

Source DB: PubMed Journal: Am J Dis Child ISSN： 0002-922X

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Cited

9 in total

1. Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model.

Authors: Krishnan MohanKumar; Niroop Kaza; Ramasamy Jagadeeswaran; Steven A Garzon; Anchal Bansal; Ashish R Kurundkar; Kopperuncholan Namachivayam; Juan I Remon; C Rekha Bandepalli; Xu Feng; Joern-Hendrik Weitkamp; Akhil Maheshwari
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-04-26 Impact factor: 4.052

Review 2. Host factors in amniotic fluid and breast milk that contribute to gut maturation.

Authors: Carol L Wagner; Sarah N Taylor; Donna Johnson
Journal: Clin Rev Allergy Immunol Date: 2008-04 Impact factor: 8.667

3. Cord blood B cells are mature in their capacity to switch to IgE-producing cells in response to interleukin-4 in vitro.

Authors: G Pastorelli; F Rousset; J Pène; C Peronne; M G Roncarolo; P A Tovo; J E de Vries
Journal: Clin Exp Immunol Date: 1990-10 Impact factor: 4.330

Monocyte-macrophage function in the newborn.

1. Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model.

Review 2. Host factors in amniotic fluid and breast milk that contribute to gut maturation.

3. Cord blood B cells are mature in their capacity to switch to IgE-producing cells in response to interleukin-4 in vitro.

4. [DMNH chemiluminescence of ingesting monocytes].

5. Phagocytic activities in neonatal monocytes.

6. Oxidative metabolism in cord blood monocytes and monocyte-derived macrophages.

7. Ontogeny of murine macrophages: functions related to antigen presentation.

8. Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling.

Review 9. Immune vulnerability of infants to tuberculosis.