Literature DB >> 9204412

Use of hepatocyte cultures for the study of hepatotoxic compounds.

A Guillouzo1, F Morel, S Langouët, K Maheo, M Rissel.   

Abstract

Human and animal hepatocytes in primary culture are widely used in pharmacotoxicological research. They represent a unique in vitro model since they retain both phase I and phase II enzyme activities as well as their inducibility by xenobiotics. Hepatocyte cultures are used for drug screening, identification of the lesions induced by toxic compounds and determination of mechanisms by which xenobiotics exert liver injury.

Entities:  

Mesh：

Year:  1997        PMID： 9204412     DOI： 10.1016/s0168-8278(97)80499-0

Source DB:  PubMed          Journal:  J Hepatol        ISSN： 0168-8278            Impact factor:   25.083


  13 in total

Review 1.  Hepatic stem cells.

Authors:  A J Strain; H A Crosby
Journal:  Gut       Date:  2000-06       Impact factor: 23.059

2.  Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.

Authors:  O B Usta; W J McCarty; S Bale; M Hegde; R Jindal; A Bhushan; I Golberg; M L Yarmush
Journal:  Technology (Singap World Sci)       Date:  2015-03

3.  Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells.

Authors:  Shyam Sundhar Bale; Inna Golberg; Rohit Jindal; William J McCarty; Martha Luitje; Manjunath Hegde; Abhinav Bhushan; Osman Berk Usta; Martin L Yarmush
Journal:  Tissue Eng Part C Methods       Date:  2014-11-06       Impact factor: 3.056

4.  Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.

Authors:  Medjda Bellamri; Ludovic Le Hegarat; Robert J Turesky; Sophie Langouët
Journal:  Chem Res Toxicol       Date:  2016-12-15       Impact factor: 3.739

5.  DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

Authors:  Gwendoline Nauwelaers; Erin E Bessette; Dan Gu; Yijin Tang; Julie Rageul; Valérie Fessard; Jian-Min Yuan; Mimi C Yu; Sophie Langouët; Robert J Turesky
Journal:  Chem Res Toxicol       Date:  2011-04-19       Impact factor: 3.739

6.  Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study.

Authors:  S Bellentani; G Pozzato; G Saccoccio; M Crovatto; L S Crocè; L Mazzoran; F Masutti; G Cristianini; C Tiribelli
Journal:  Gut       Date:  1999-06       Impact factor: 23.059

7.  13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for organ toxicity.

Authors:  H Spielmann; N P Bochkov; L Costa; L Gribaldo; A Guillouzo; J J Heindel; M Karol; R Parchment; W Pfaller; P P Peraita; T Zacharewski
Journal:  Environ Health Perspect       Date:  1998-04       Impact factor: 9.031

8.  A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture.

Authors:  William J McCarty; O Berk Usta; Martha Luitje; Shyam Sundhar Bale; Abhinav Bhushan; Manjunath Hegde; Inna Golberg; Rohit Jindal; Martin L Yarmush
Journal:  Technology (Singap World Sci)       Date:  2014-03

9.  DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.

Authors:  Gwendoline Nauwelaërs; Medjda Bellamri; Valérie Fessard; Robert J Turesky; Sophie Langouët
Journal:  Chem Res Toxicol       Date:  2013-08-16       Impact factor: 3.739

10.  Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph.

Authors:  Yoshinori Inagaki; Yasuhiko Matsumoto; Keiko Kataoka; Naoya Matsuhashi; Kazuhisa Sekimizu
Journal:  BMC Pharmacol Toxicol       Date:  2012-11-08       Impact factor: 2.483
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