Literature DB >> 9202609

Occurrence of myeloproliferative disorder in patients with Noonan syndrome.

B Bader-Meunier1, G Tchernia, F Miélot, J L Fontaine, C Thomas, S Lyonnet, J M Lavergne, J P Dommergues.   

Abstract

We report four cases of Noonan syndrome associated with chronic myelomonocytic leukemia in childhood. These children shared some hematologic features: thrombocytopenia, splenomegaly in the first months of life, occurrence of chronic myelomonocytic leukemia without abnormalities of the initial bone marrow karyotype, and, in three cases, improvement of the hematologic disease. A common pathophysiologic process in such patients is suggested.

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Year:  1997        PMID： 9202609     DOI： 10.1016/s0022-3476(97)70273-7

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  41 in total

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Journal:  Eur J Hum Genet       Date:  2016-01-13       Impact factor: 4.246

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Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-12       Impact factor: 11.205

9.  PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.

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Journal:  Blood       Date:  2006-10-19       Impact factor: 22.113

10.  Severe congenital thrombocytopaenia--first clinical manifestation of Noonan syndrome.

Authors:  Paula Nunes; Sara Aguilar; Sara Noéme Prado; Maria João Palaré; Anabela Ferrão; Anabela Morais
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