Literature DB >> 9202163

Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8-hydroxy-2'-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment.

M Erhola1, S Toyokuni, K Okada, T Tanaka, H Hiai, H Ochi, K Uchida, T Osawa, M M Nieminen, H Alho, P Kellokumpu-Lehtinen.   

Abstract

Ratios of urinary 8-hydroxy-2'-deoxyguanosine to urinary creatinine (8-OHdG/creatinine) have been considered as a good biological indicator of DNA oxidation. Urinary 8-OHdG/creatinine levels of lung cancer patients were evaluated by enzyme-linked immunosorbent assay using a monoclonal antibody N45.1 during radiotherapy and chemotherapy. An increase in urinary 8-OHdG/creatinine was found in non-small-cell carcinoma (non-SCC) patients during the course of radiotherapy. SCC patients showed higher levels of urinary 8-OHdG/creatinine than the controls. Furthermore, SCC patients with complete or partial response to the chemotherapy showed a significant decrease in urinary 8-OHdG/creatinine while patients with no change or progressive disease showed an increase.

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Year:  1997        PMID： 9202163     DOI： 10.1016/s0014-5793(97)00523-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  47 in total

1.  Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study.

Authors:  Cizao Ren; Shona Fang; Robert O Wright; Helen Suh; Joel Schwartz
Journal:  Occup Environ Med       Date:  2010-10-27       Impact factor: 4.402

2.  Effects of an antioxidant beverage on biomarkers of oxidative stress in Alzheimer's patients.

Authors:  Jose M Rubio-Perez; Maria D Albaladejo; Pilar Zafrilla; Maria L Vidal-Guevara; Juana M Morillas-Ruiz
Journal:  Eur J Nutr       Date:  2015-08-23       Impact factor: 5.614

3.  Determination of 8-oxoguanine and 8-hydroxy-2'-deoxyguanosine in the rat cerebral cortex using microdialysis sampling and capillary electrophoresis with electrochemical detection.

Authors:  Stacy D Arnett; Damon M Osbourn; Kimberly D Moore; Shannon S Vandaveer; Craig E Lunte
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2005-07-01       Impact factor: 3.205

Review 4.  8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures.

Authors:  A Pilger; H W Rüdiger
Journal:  Int Arch Occup Environ Health       Date:  2006-05-10       Impact factor: 3.015

5.  8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress.

Authors:  Clementina Mesaros; Jasbir S Arora; Ashley Wholer; Anil Vachani; Ian A Blair
Journal:  Free Radic Biol Med       Date:  2012-05-18       Impact factor: 7.376

6.  Seasonal and annual variations of metal uptake, bioaccumulation, and toxicity in Trifolium repens and Lolium perenne growing in a heavy metal-contaminated field.

Authors:  Géraldine Bidar; Christelle Pruvot; Guillaume Garçon; Anthony Verdin; Pirouz Shirali; Francis Douay
Journal:  Environ Sci Pollut Res Int       Date:  2008-07-02       Impact factor: 4.223

7.  Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study.

Authors:  Chunfang Qiu; Karin Hevner; Dejene Abetew; Daniel A Enquobahrie; Michelle A Williams
Journal:  Clin Biochem       Date:  2011-05-13       Impact factor: 3.281

8.  Nutritional prevention on hypertension, cerebral hemodynamics and thrombosis in stroke-prone spontaneously hypertensive rats.

Authors:  Takanori Noguchi; Katsumi Ikeda; Yasuto Sasaki; Yukio Yamori
Journal:  Cell Mol Neurobiol       Date:  2004-10       Impact factor: 5.046

9.  Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.

Authors:  Jee Young Kim; Lacey A Prouty; Shona C Fang; Ema G Rodrigues; Shannon R Magari; Geoffrey A Modest; David C Christiani
Journal:  J Occup Environ Med       Date:  2009-10       Impact factor: 2.162

10.  Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine.

Authors:  Marcus S Cooke; Paul T Henderson; Mark D Evans
Journal:  J Clin Biochem Nutr       Date:  2009-10-28       Impact factor: 3.114
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