Literature DB >> 9202161

Molecular cloning and expression of a bovine endothelial inward rectifier potassium channel.

S E Forsyth1, A Hoger, J H Hoger.   

Abstract

A 5.1 kb cDNA encoding an inward rectifier K+ channel (BIK) was isolated from a bovine aortic endothelial cell library. The cDNA codes for a 427-amino-acid protein with two putative transmembrane regions. Sequence analysis reveals that BIK is a member of the Kir2.1 family of inward rectifier K+ channels. Expression in Xenopus oocytes showed that BIK is a K+-specific strong inward rectifier channel that is sensitive to extracellular Ba2+, Cs+, and a variety of anti-arrhythmic agents. Northern analysis revealed that endothelial cells express a 5.5 kb BIK mRNA that is sensitive to shear stress.

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Year:  1997        PMID： 9202161     DOI： 10.1016/s0014-5793(97)00514-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Shear stress regulates the endothelial Kir2.1 ion channel.

Authors:  Jeff H Hoger; Victor I Ilyin; Scott Forsyth; Anne Hoger
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

2.  An inwardly rectifying K+ channel in bovine parotid acinar cells: possible involvement of Kir2.1.

Authors:  M Hayashi; S Komazaki; T Ishikawa
Journal:  J Physiol       Date:  2003-01-03       Impact factor: 5.182

3.  Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.

Authors:  C Töpert; F Döring; E Wischmeyer; C Karschin; J Brockhaus; K Ballanyi; C Derst; A Karschin
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

4.  Mechanisms for the time-dependent decay of inward currents through cloned Kir2.1 channels expressed in Xenopus oocytes.

Authors:  R C Shieh
Journal:  J Physiol       Date:  2000-07-15       Impact factor: 5.182

Review 5.  Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR).

Authors:  Stine F Pedersen; Yasunobu Okada; Bernd Nilius
Journal:  Pflugers Arch       Date:  2016-01-06       Impact factor: 3.657

6.  Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol.

Authors:  Victor G Romanenko; George H Rothblat; Irena Levitan
Journal:  Biophys J       Date:  2002-12       Impact factor: 4.033

7.  Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels.

Authors:  Victor G Romanenko; Yun Fang; Fitzroy Byfield; Alexander J Travis; Carol A Vandenberg; George H Rothblat; Irena Levitan
Journal:  Biophys J       Date:  2004-10-01       Impact factor: 4.033

8.  Ca2+-activated K+ channels in murine endothelial cells: block by intracellular calcium and magnesium.

Authors:  Jonathan Ledoux; Adrian D Bonev; Mark T Nelson
Journal:  J Gen Physiol       Date:  2008-01-14       Impact factor: 4.086

Review 9.  Cholesterol and Kir channels.

Authors:  Irena Levitan
Journal:  IUBMB Life       Date:  2009-08       Impact factor: 3.885

Review 10.  Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress.

Authors:  Shi Pan
Journal:  Antioxid Redox Signal       Date:  2009-07       Impact factor: 8.401
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