| Literature DB >> 9201939 |
G Zardo1, M D'Erme, A Reale, R Strom, M Perilli, P Caiafa.
Abstract
The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a well-known inhibitor of poly(ADP-ribose) polymerase. Both experimental approaches evidenced a close relationship between these two important nuclear enzymatic mechanisms, suggesting that the poly(ADP-ribosyl)ated isoform of H1 histone and/or long and branched protein-free ADP-ribose polymers could act as protecting agents against full methylation of the CpG dinucleotides in genomic DNA.Entities:
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Year: 1997 PMID： 9201939 DOI： 10.1021/bi970241s
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162