OBJECTIVE: To compare the effects of dopexamine and dopamine on the mucosal permeability of the gastrointestinal tract (GIT). DESIGN: Prospective, randomised clinical trial. SETTING:Intensive care unit of a postgraduate teaching hospital, London, England. PATIENTS: Thirty patients undergoing elective surgery involving cardiopulmonary bypass, performed by a single surgeon. INTERVENTIONS: Patients were randomly assigned to receive either dopexamine 2.0 micrograms/kg per min or dopamine 2.5 micrograms/kg per min for the duration of the study period. MEASUREMENTS AND MAIN RESULTS:Hemodynamic parameters and gastric intramucosal pH (pHi) were measured at intervals throughout the study. GIT permeability was measured once, post-operatively, using the ratio of absorbed lactulose to L-rhamnose. The groups were similar with respect to demographics, pre- and post-operative risk factors. The lactulose/rhamnose ratio was (mean +/- SEM) 0.44 +/- 0.10 in the dopexamine group vs 0.65 +/- 0.08 in that receiving dopamine (p < 0.05). The dopexamine group had a significantly higher oxygen delivery preoperatively (479.5 +/- 32.0 ml/min per m2 vs 344.4 +/- 23.9 ml/min per m2 for dopamine, p < 0.01), but no other significant differences emerged between the groups. CONCLUSIONS: Compared to dopamine, dopexamine reduces GIT permeability following surgery involving cardiopulmonary bypass. The mechanism of this effect remains unclear.
RCT Entities:
OBJECTIVE: To compare the effects of dopexamine and dopamine on the mucosal permeability of the gastrointestinal tract (GIT). DESIGN: Prospective, randomised clinical trial. SETTING: Intensive care unit of a postgraduate teaching hospital, London, England. PATIENTS: Thirty patients undergoing elective surgery involving cardiopulmonary bypass, performed by a single surgeon. INTERVENTIONS:Patients were randomly assigned to receive either dopexamine 2.0 micrograms/kg per min or dopamine 2.5 micrograms/kg per min for the duration of the study period. MEASUREMENTS AND MAIN RESULTS: Hemodynamic parameters and gastric intramucosal pH (pHi) were measured at intervals throughout the study. GIT permeability was measured once, post-operatively, using the ratio of absorbed lactulose to L-rhamnose. The groups were similar with respect to demographics, pre- and post-operative risk factors. The lactulose/rhamnose ratio was (mean +/- SEM) 0.44 +/- 0.10 in the dopexamine group vs 0.65 +/- 0.08 in that receiving dopamine (p < 0.05). The dopexamine group had a significantly higher oxygen delivery preoperatively (479.5 +/- 32.0 ml/min per m2 vs 344.4 +/- 23.9 ml/min per m2 for dopamine, p < 0.01), but no other significant differences emerged between the groups. CONCLUSIONS: Compared to dopamine, dopexamine reduces GIT permeability following surgery involving cardiopulmonary bypass. The mechanism of this effect remains unclear.
Authors: J García-Arnés; C Sierra; F Tinahones; A Monzón; M J López; N Mazuecos; F Soriguer; E Valverde Journal: J Endocrinol Invest Date: 2001-02 Impact factor: 4.256