S Savaşan1, V Tuzcu, I Warrier, P Karpawich. 1. Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, USA.
Abstract
PURPOSE: Several side effects of intravenous immunoglobulin G (IVIG) therapy are known, but it has never been reported to be associated with cardiac rhythm abnormalities other than sinus tachycardia. PATIENTS AND METHODS: We describe the development of cardiac dysrhythmias during intravenous immunoglobulin G infusion in two children with thrombocytopenia. One of the patients had a history of supraventricular tachycardia, and the other had evidence suggestive of preexisting long QT syndrome. CONCLUSION: Cardiac rhythm abnormalities may be exacerbated in individuals with preexisting cardiac problems by IVIG infusion, and such patients should be monitored closely during IVIG administration.
PURPOSE: Several side effects of intravenous immunoglobulin G (IVIG) therapy are known, but it has never been reported to be associated with cardiac rhythm abnormalities other than sinus tachycardia. PATIENTS AND METHODS: We describe the development of cardiac dysrhythmias during intravenous immunoglobulin G infusion in two children with thrombocytopenia. One of the patients had a history of supraventricular tachycardia, and the other had evidence suggestive of preexisting long QT syndrome. CONCLUSION:Cardiac rhythm abnormalities may be exacerbated in individuals with preexisting cardiac problems by IVIG infusion, and such patients should be monitored closely during IVIG administration.