Literature DB >> 9200615

The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release.

A B Parekh1, A Fleig, R Penner.   

Abstract

Patch-clamp experiments aimed at determining the relationship between intracellular Ca2+ release and activation of store-operated calcium current I(CRAC) reveal that both agonist and InsP3-mediated activation of I(CRAC) are highly nonlinear, occurring over a narrow concentration range. Ca2+ release and Ca2+ influx can be dissociated, as they possess differential sensitivities to InsP3: low concentrations induce substantial Ca2+ release without any activation of I(CRAC), whereas micromolar concentrations of InsP3 are required to activate Ca2+ influx. This suggests functionally distinct stores controlling Ca2+ release and influx and enables cells to switch between sources of Ca2+ to fit best their current needs.

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Year:  1997        PMID： 9200615     DOI： 10.1016/s0092-8674(00)80282-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  77 in total

1.  On the characterisation of the mechanism underlying passive activation of the Ca2+ release-activated Ca2+ current ICRAC in rat basophilic leukaemia cells.

Authors:  L Fierro; A B Parekh
Journal:  J Physiol       Date:  1999-10-15       Impact factor: 5.182

2.  Ca2+ store dynamics determines the pattern of activation of the store-operated Ca2+ current I(CRAC) in response to InsP3 in rat basophilic leukaemia cells.

Authors:  M D Glitsch; A B Parekh
Journal:  J Physiol       Date:  2000-03-01       Impact factor: 5.182

3.  Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca(2+) current I(CRAC).

Authors:  J A Gilabert; A B Parekh
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

4.  Voltage-dependent conductance changes in the store-operated Ca2+ current ICRAC in rat basophilic leukaemia cells.

Authors:  D Bakowski; A B Parekh
Journal:  J Physiol       Date:  2000-12-01       Impact factor: 5.182

5.  Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx.

Authors:  J A Gilabert; D Bakowski; A B Parekh
Journal:  EMBO J       Date:  2001-06-01       Impact factor: 11.598

6.  A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin.

Authors:  L M Broad; T R Cannon; C W Taylor
Journal:  J Physiol       Date:  1999-05-15       Impact factor: 5.182

7.  Depletion of Ca2+ in the sarcoplasmic reticulum stimulates Ca2+ entry into mouse skeletal muscle fibres.

Authors:  N Kurebayashi; Y Ogawa
Journal:  J Physiol       Date:  2001-05-15       Impact factor: 5.182

8.  Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.

Authors:  Anant B Parekh
Journal:  J Physiol       Date:  2003-02-07       Impact factor: 5.182

Review 9.  Role of TRP ion channels in cancer and tumorigenesis.

Authors:  George Shapovalov; Abigael Ritaine; Roman Skryma; Natalia Prevarskaya
Journal:  Semin Immunopathol       Date:  2016-02-03       Impact factor: 9.623

10.  Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

Authors:  Motohiro Nishida; Kenji Sugimoto; Yuji Hara; Emiko Mori; Takashi Morii; Tomohiro Kurosaki; Yasuo Mori
Journal:  EMBO J       Date:  2003-09-15       Impact factor: 11.598
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