BACKGROUND: The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is controversial. METHODS: In a prospective, long-term, double-blind study we randomized 100 patients with non-ulcer dyspepsia and H. pylori infection to receive either of two treatment regimens: 1) bismuth-based triple therapy (n = 50) or 2) bismuth + placebo (n = 50). RESULTS: Triple therapy: subjects who became H. pylori-negative (n = 42) showed a significant symptomatic response when interviewed at 8 weeks, 6 months, and 1 year (P < 0.01). This improvement was evident in the 'ulcer-like' dyspepsia group at all times (P < 0.01) but in the 'reflux-like' and 'motility-like' groups at 6 months only (P < 0.01). Those who remained H. pylori-positive showed no decrease in symptoms at 8 weeks, 6 months, and 1 year. Bismuth-placebotherapy: subjects who became H. pylori-negative (n = 7) showed an improvement in symptoms at 8 weeks, 6 months, and 1 year. Those who continued to harbour the infection after treatment (n = 42) showed an insignificant improvement in the motility and non-specific groups only. CONCLUSION: This study shows that eradication of H. pylori results in a significant long-term reduction in symptoms of non-ulcer dyspepsia.
RCT Entities:
BACKGROUND: The relationship between Helicobacter pyloriinfection and non-ulcer dyspepsia is controversial. METHODS: In a prospective, long-term, double-blind study we randomized 100 patients with non-ulcer dyspepsia and H. pyloriinfection to receive either of two treatment regimens: 1) bismuth-based triple therapy (n = 50) or 2) bismuth + placebo (n = 50). RESULTS: Triple therapy: subjects who became H. pylori-negative (n = 42) showed a significant symptomatic response when interviewed at 8 weeks, 6 months, and 1 year (P < 0.01). This improvement was evident in the 'ulcer-like' dyspepsia group at all times (P < 0.01) but in the 'reflux-like' and 'motility-like' groups at 6 months only (P < 0.01). Those who remained H. pylori-positive showed no decrease in symptoms at 8 weeks, 6 months, and 1 year. Bismuth-placebo therapy: subjects who became H. pylori-negative (n = 7) showed an improvement in symptoms at 8 weeks, 6 months, and 1 year. Those who continued to harbour the infection after treatment (n = 42) showed an insignificant improvement in the motility and non-specific groups only. CONCLUSION: This study shows that eradication of H. pylori results in a significant long-term reduction in symptoms of non-ulcer dyspepsia.
Authors: Francesco di Mario; Nicoletta Stefani; Nadia Dal Bò; Massimo Rugge; Alberto Pilotto; Giulia Martina Cavestro; Lucas Giovanni Cavallaro; Angelo Franzé; Gioacchino Leandro Journal: Dig Dis Sci Date: 2005-12 Impact factor: 3.199
Authors: S J Veldhuyzen van Zanten; N Flook; N Chiba; D Armstrong; A Barkun; M Bradette; A Thomson; F Bursey; P Blackshaw; D Frail; P Sinclair Journal: CMAJ Date: 2000-06-13 Impact factor: 8.262