Literature DB >> 9199967

CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection.

Y Murayama1, A Amano, R Mukai, H Shibata, S Matsunaga, H Takahashi, Y Yoshikawa, M Hayami, A Noguchi.   

Abstract

We found that most peripheral CD4 cells co-express a low density of CD8 alpha antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8low cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8low cells were resistant to SIV infection after their conversion to CD4- cells.

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Year:  1997        PMID： 9199967     DOI： 10.1093/intimm/9.6.843

Source DB:  PubMed          Journal:  Int Immunol        ISSN： 0953-8178            Impact factor:   4.823


  25 in total

1.  Wide range of viral load in healthy african green monkeys naturally infected with simian immunodeficiency virus.

Authors:  S Goldstein; I Ourmanov; C R Brown; B E Beer; W R Elkins; R Plishka; A Buckler-White; V M Hirsch
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

2.  Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys.

Authors:  Joseph C Mudd; Molly R Perkins; Sarah R DiNapoli; Vanessa M Hirsch; Jason M Brenchley
Journal:  J Virol       Date:  2016-05-27       Impact factor: 5.103

3.  Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts.

Authors:  Ivona Pandrea; Cristian Apetrei; Jason Dufour; Nora Dillon; Joseph Barbercheck; Michael Metzger; Béatrice Jacquelin; Rudolf Bohm; Preston A Marx; Françoise Barre-Sinoussi; Vanessa M Hirsch; Michaela C Müller-Trutwin; Andrew A Lackner; Ronald S Veazey
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

4.  Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease.

Authors:  S R Broussard; S I Staprans; R White; E M Whitehead; M B Feinberg; J S Allan
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

5.  Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys.

Authors:  Carol L Vinton; Alexandra M Ortiz; Nina Calantone; Joseph C Mudd; Claire Deleage; David R Morcock; Sonya Whitted; Jacob D Estes; Vanessa M Hirsch; Jason M Brenchley
Journal:  J Immunol       Date:  2017-04-24       Impact factor: 5.422

6.  Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors.

Authors:  Nadeene E Riddick; Fan Wu; Kenta Matsuda; Sonya Whitted; Ilnour Ourmanov; Simoy Goldstein; Robert M Goeken; Ronald J Plishka; Alicia Buckler-White; Jason M Brenchley; Vanessa M Hirsch
Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

7.  Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.

Authors:  Roland C Zahn; Melisa D Rett; Birgit Korioth-Schmitz; Yue Sun; Adam P Buzby; Simoy Goldstein; Charles R Brown; Russell A Byrum; Gordon J Freeman; Norman L Letvin; Vanessa M Hirsch; Jörn E Schmitz
Journal:  J Virol       Date:  2008-10-01       Impact factor: 5.103

Review 8.  Where the wild things are: pathogenesis of SIV infection in African nonhuman primate hosts.

Authors:  Ivona Pandrea; Cristian Apetrei
Journal:  Curr HIV/AIDS Rep       Date:  2010-02       Impact factor: 5.071

9.  Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.

Authors:  Molly R Perkins; Judith A Briant; Nina Calantone; Sonya Whitted; Carol L Vinton; Nichole R Klatt; Ilnour Ourmanov; Alexandra M Ortiz; Vanessa M Hirsch; Jason M Brenchley
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

10.  CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.

Authors:  Coreen M Beaumier; Levelle D Harris; Simoy Goldstein; Nichole R Klatt; Sonya Whitted; John McGinty; Cristian Apetrei; Ivona Pandrea; Vanessa M Hirsch; Jason M Brenchley
Journal:  Nat Med       Date:  2009-06-14       Impact factor: 53.440
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