| Literature DB >> 9199875 |
L Paemen1, P M Jansen, P Proost, J Van Damme, G Opdenakker, E Hack, F B Taylor.
Abstract
Intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9199875 DOI： 10.1006/cyto.1996.0183
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861