| Literature DB >> 9198172 |
R R Thiagarajan1, R K Winn, J M Harlan.
Abstract
Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.Entities:
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Year: 1997 PMID: 9198172
Source DB: PubMed Journal: Thromb Haemost ISSN: 0340-6245 Impact factor: 5.249