Literature DB >> 9197533

Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers.

Y Sakurai1, Y Otani, K Kameyama, Y Hosoda, I Okazaki, T Kubota, K Kumai, M Kitajima.   

Abstract

The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

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Year:  1997        PMID： 9197533      PMCID： PMC5921419          DOI： 10.1111/j.1349-7006.1997.tb00396.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


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