| Literature DB >> 9197523 |
C Maesawa1, G Tamura, S Nishizuka, T Iwaya, S Ogasawara, K Ishida, K Sakata, N Sato, K Ikeda, Y Kimura, K Saito, R Satodate.
Abstract
The MAD (mothers against decapentaplegic)-related genes, Smad2 (former name MADR2 or JV18-1) and Smad4 (former name DPC4), have been identified on chromosome 18q21.1. We analyzed 30 primary esophageal squamous cell carcinomas (ESCC) and 7 cell lines derived from ESCC for intragenic mutations and loss of heterozygosity (LOH) of the Smad2 and Smad4 genes. LOH was detected in 5 of 14 (35%) informative cases. However, no mutations in either gene were detected in either the primary carcinomas or the cell lines, and only a G-to-A base transition within the 3'-untranslated region of the Smad4 gene was observed in a carcinoma. There were no homozygous deletions in either of the genes in the cell lines. MAD-related genes on chromosome 18q21.1 are altered infrequently in ESCC.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9197523 PMCID： PMC5921430 DOI： 10.1111/j.1349-7006.1997.tb00386.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050