Human factor-dependent leukemia cell lines.

To date several factor-dependent leukemia cell lines have been established. These cell lines have greatly contributed to the analyses of cytokine-mediated cellular signaling mechanisms involved in cell proliferation, differentiation and survival. In addition, they are ideal and practical models for testing the hypothesis regarding leukemogenesis. Taken together, factor-dependent leukemia cell lines are expected to be useful for studies on cell biology and development of new cancer therapeutics.