Literature DB >> 9193764

Stressor-induced alterations in immune response and viral clearance following infection with herpes simplex virus-type 1 in BALB/c and C57B1/6 mice.

G J Brenner1, J A Moynihan.   

Abstract

Extending earlier studies of stress-induced modulation of herpes simplex virus (HSV) infection and immunity, we investigated the effects of electric foot shock (0.3 mA) on cytokine production and immune effector function in response to a nonlethal inoculum of HSV-1 in two strains of inbred mice, C57B1/6 and BALB/c. Increased levels of infectious virus at the site of infection were observed in foot-shocked mice of both strains compared to control mice. The specific pattern of changes in interleukin (IL)-2 and interferon-gamma, as well as IL-4 and IL-10, induced by foot-shock stress differed between the two strains. IgM anti-HSV antibody responses were, however, increased in both strains.

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Year:  1997        PMID： 9193764     DOI： 10.1006/brbi.1997.0480

Source DB:  PubMed          Journal:  Brain Behav Immun        ISSN： 0889-1591            Impact factor:   7.217


  5 in total

1.  Intracellular expression of c-Fos protein in various structures of the hypothalamus in electrical pain stimulation and administration of antigens.

Authors:  Yu V Gavrilov; S V Perekrest; N S Novikova
Journal:  Neurosci Behav Physiol       Date:  2008-01

2.  Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses.

Authors:  Kathleen A Ashcraft; Robert H Bonneau
Journal:  Brain Behav Immun       Date:  2008-06-27       Impact factor: 7.217

3.  Stress-induced changes in cellular responses in hypothalamic structures to administration of an antigen (lipopolysaccharide) (in terms of c-Fos protein expression).

Authors:  Yu V Gavrilov; S V Perekrest; N S Novikova; E A Korneva
Journal:  Neurosci Behav Physiol       Date:  2008-02

4.  Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.

Authors:  Kathleen A Ashcraft; John Hunzeker; Robert H Bonneau
Journal:  Psychoneuroendocrinology       Date:  2008-07-25       Impact factor: 4.905

5.  Species diversity concurrently dilutes and amplifies transmission in a zoonotic host-pathogen system through competing mechanisms.

Authors:  Angela D Luis; Amy J Kuenzi; James N Mills
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-16       Impact factor: 11.205
  5 in total

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