| Literature DB >> 9193761 |
S Oziel-Taieb1, C Faucher-Barbey, C Chabannon, P Ladaique, P Saux, F Gouin, J A Gastaut, D Maraninchi, D Blaise.
Abstract
A 38-year-old man, blood group A+, was allotransplanted for multiple myeloma from his fully matched sister, blood group O+. Anti-A antibodies IgG and IgM titres of the donor were low. Allogeneic peripheral blood stem cells were harvested by leukapheresis after subcutaneous administration of G-CSF. Rapid engraftment occurred since 5.6 x 10(9)/l leukocytes were achieved on day +9 post-transplant. At this time a severe immune haemolytic syndrome occurred and direct antiglobulin test was positive (IgG and C3d). Elution showed an anti-A specificity. Evolution was rapidly unfavourable related to multiorgan failure. The patient died on day +20 post-transplant.Entities:
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Year: 1997 PMID： 9193761 DOI： 10.1038/sj.bmt.1700794
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483