Literature DB >> 9192970

Determination of 3D dose distribution from intracavitary brachytherapy of cervical cancer by MRI of irradiated ferrous sulphate gel.

B H Knutsen1, A Skretting, T P Hellebust, D R Olsen.   

Abstract

BACKGROUND AND
PURPOSE: MRI ferrous sulphate gel dosimetry has proven to be a valuable method for assessment of dose delivered in teletherapy. The intention of this study was to investigate ferrous sulphate gel as a possible dosimeter for intracavitary brachytherapy applications.
MATERIALS AND METHODS: A plastic duplicate of a cervix ring applicator set was submerged in Fe2(+)-infused gelatin gel. The gel was subsequently irradiated by a stepwise moving 192Ir source, using automatic afterloading equipment (Microselectron, Nucletron-Oldelft International BV, Veenendaal, The Netherlands). A 3D dose distribution was reconstructed from MR images of the gel.
RESULTS: The gel dose measurements were found to be of the same accuracy as TLD measurements. Isodose curves based on gel dosimetry and isodose curves computed by a dose planning system were generally less than 2 mm apart. MR images showing the position of the applicator set in a patient during treatment were used to obtain images describing patient anatomy in the sagittal and ring planes of the applicator set. Isodose curves computed from the gel measurements were then superimposed on these images, illustrating one possible way of linking dosimetrical and anatomical data.
CONCLUSIONS: Our study shows that MRI ferrous sulphate gel dosimetry is a useful tool for studies of dose distributions in brachytherapy and their relation to critical organs. Possible improvements of the gel dosimeter lie in reducing the diffusion of ferric ions and increasing the radiation sensitivity of the gel.

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Year:  1997        PMID: 9192970     DOI: 10.1016/s0167-8140(97)01925-7

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN: 0167-8140            Impact factor:   6.280


  2 in total

1.  Determination of paramagnetic ferrous gel sensitivity in low energy x-ray beam produced by a miniature accelerator.

Authors:  Yassir Ben Ahmed; Jérémy Coulaud; Soléakhena Ken; Laure Parent
Journal:  PLoS One       Date:  2020-05-04       Impact factor: 3.240

Review 2.  Radiation Dosimetry by Use of Radiosensitive Hydrogels and Polymers: Mechanisms, State-of-the-Art and Perspective from 3D to 4D.

Authors:  Yves De Deene
Journal:  Gels       Date:  2022-09-19
  2 in total

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