Literature DB >> 9192515

Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).

O Teronen1, Y T Konttinen, C Lindqvist, T Salo, T Ingman, A Lauhio, Y Ding, S Santavirta, H Valleala, T Sorsa.   

Abstract

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

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Year:  1997        PMID： 9192515     DOI： 10.1007/s002239900295

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  12 in total

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Review 2.  Diagnostic biomarkers for oral and periodontal diseases.

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Journal:  Dent Clin North Am       Date:  2005-07

Review 3.  Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.

Authors:  Thomas J Wilson; Rakesh K Singh
Journal:  Biochim Biophys Acta       Date:  2007-11-26

4.  Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice.

Authors:  M E Stearns; M Wang
Journal:  Clin Exp Metastasis       Date:  1998-11       Impact factor: 5.150

5.  Intramuscular clodronate in erosive osteoarthritis of the hand is effective on pain and reduces serum COMP: a randomized pilot trial-The ER.O.D.E. study (ERosive Osteoarthritis and Disodium-clodronate Evaluation).

Authors:  Luca Dalle Carbonare; Gianantonio Saviola; Lul Abdi-Ali; Maria Rosaria Povino; Lorella Campostrini; Silvano Sacco
Journal:  Clin Rheumatol       Date:  2017-05-23       Impact factor: 2.980

Review 6.  An odyssey from breast to bone: multi-step control of mammary metastases and osteolysis by matrix metalloproteinases.

Authors:  A Lochter; M J Bissell
Journal:  APMIS       Date:  1999-01       Impact factor: 3.205

7.  Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines.

Authors:  Marie R Webster; Chandrashekhar Kamat; Nick Connis; Ming Zhao; Ashani T Weeraratna; Michelle A Rudek; Christine L Hann; Caren L Freel Meyers
Journal:  Mol Cancer Ther       Date:  2013-12-05       Impact factor: 6.261

Review 8.  Clodronate: new directions of use.

Authors:  Bruno Frediani; Ilaria Bertoldi
Journal:  Clin Cases Miner Bone Metab       Date:  2015-10-26

9.  Intra-articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect.

Authors:  B Murat Cınar; Gurkan Ozkoc; Filiz Bolat; Oguz Karaeminogullari; Nurzen Sezgin; Reha N Tandogan
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-03-25       Impact factor: 4.342

10.  The Effect of Epigallocatechin Gallate on the Dentin Bond Durability of Two Self-etch Adhesives.

Authors:  Zahra Khamverdi; Loghman Rezaei-Soufi; Tayebeh Rostamzadeh
Journal:  J Dent (Shiraz)       Date:  2015-06
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