Literature DB >> 9191894

Genetic factors influencing alpha-particle-induced chromosomal instability.

G E Watson1, S A Lorimore, S M Clutton, M A Kadhim, E G Wright.   

Abstract

Alpha-particle-induced chromosomal instability in haemopoietic cells obtained from the CBA/H, DBA/2 and C57BL/6 inbred strains of mouse has been demonstrated at frequencies dependent on genotype. The CBA/H and DBA/2 strains may be regarded as 'sensitive' and the C57BL/6 strain as 'resistant'; resistance was dominant in cells from F1 hybrids. Previously, in cultures where we demonstrated radiation-induced chromosomal instability we also demonstrated an enhanced and persisting oxyradical activity. Quantitative differences in superoxide generation have now been correlated with genetically determined differences in the expression of chromosomal instability. Our findings demonstrate an important influence of genetic factors in alpha-particle-induced chromosomal instability.

Entities:  

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Year:  1997        PMID： 9191894     DOI： 10.1080/095530097143824

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  13 in total

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3.  Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation.

Authors:  S A Lorimore; M A Kadhim; D A Pocock; D Papworth; D L Stevens; D T Goodhead; E G Wright
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4.  Ionizing radiation induces delayed hyperrecombination in Mammalian cells.

Authors:  Lei Huang; Suzanne Grim; Leslie E Smith; Perry M Kim; Jac A Nickoloff; Olga G Goloubeva; William F Morgan
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

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6.  Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins.

Authors:  R S Camplejohn; S Hodgson; N Carter; B S Kato; T D Spector
Journal:  Br J Cancer       Date:  2006-07-04       Impact factor: 7.640

Review 7.  Role of nitric oxide in the radiation-induced bystander effect.

Authors:  Vasily A Yakovlev
Journal:  Redox Biol       Date:  2015-09-01       Impact factor: 11.799

8.  Response to Baverstock, K. Comments on Rithidech, K.N.; et al. Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation. Int. J. Environ. Res. Public Health 2013, 10, 1356-1377.

Authors:  Kanokporn Noy Rithidech; Chatchanok Udomtanakunchai; Louise Honikel; Elbert Whorton
Journal:  Int J Environ Res Public Health       Date:  2013-07-02       Impact factor: 3.390

9.  Epigenetics in radiation biology: a new research frontier.

Authors:  Matt Merrifield; Olga Kovalchuk
Journal:  Front Genet       Date:  2013-04-04       Impact factor: 4.599

10.  Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells.

Authors:  N Coen; M A Kadhim; E G Wright; C P Case; C E Mothersill
Journal:  Br J Cancer       Date:  2003-02-24       Impact factor: 7.640
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