S R Shackford1. 1. Department of Surgery, University of Vermont, Burlington 05401, USA.
Abstract
BACKGROUND: Head injury outcome is adversely affected by the presence of hypotension. Therapies directed at rapidly correcting hypotension may improve outcome. METHODS: In two separate studies, we investigated small-volume resuscitation (4 mL/kg) using Ringer's lactate, hypertonic saline and dextran, and diaspirin cross-linked hemoglobin in a porcine model of cryogenic brain injury and shock. RESULTS: Small-volume resuscitation with hypertonic saline and dextran and diaspirin cross-linked hemoglobin significantly improved mean arterial pressure and cerebral perfusion pressure compared with Ringer's lactate. These data suggest that small-volume resuscitation with hypertonic saline and dextran or diaspirin cross-linked hemoglobin may effectively limit or prevent secondary ischemic brain injury after head injury and shock.
BACKGROUND:Head injury outcome is adversely affected by the presence of hypotension. Therapies directed at rapidly correcting hypotension may improve outcome. METHODS: In two separate studies, we investigated small-volume resuscitation (4 mL/kg) using Ringer's lactate, hypertonicsaline and dextran, and diaspirin cross-linked hemoglobin in a porcine model of cryogenic brain injury and shock. RESULTS: Small-volume resuscitation with hypertonicsaline and dextran and diaspirin cross-linked hemoglobin significantly improved mean arterial pressure and cerebral perfusion pressure compared with Ringer's lactate. These data suggest that small-volume resuscitation with hypertonicsaline and dextran or diaspirin cross-linked hemoglobin may effectively limit or prevent secondary ischemic brain injury after head injury and shock.
Authors: Alia Marie Dennis; M Lee Haselkorn; Vincent A Vagni; Robert H Garman; Keri Janesko-Feldman; Hülya Bayir; Robert S B Clark; Larry W Jenkins; C Edward Dixon; Patrick M Kochanek Journal: J Neurotrauma Date: 2009-06 Impact factor: 5.269