Literature DB >> 9189895

Sleep deprivation increases brain serotonin turnover in the rat.

M Asikainen1, J Toppila, L Alanko, D J Ward, D Stenberg, T Porkka-Heiskanen.   

Abstract

IN order to study possible time-dependent changes in serotonin metabolism in rat brain, male Wistar rats were subjected to 3, 6 or 12 h total sleep deprivation (SD) by gentle handling. In addition two groups of rats subjected first to 6 h SD were allowed 2 or 4 h rebound sleep. Tissue concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured from several brain areas using HPLC/ECD. SD significantly increased the 5-HIAA/5-HT ratio in frontal cortex, hippocampus, hypothalamus and brain stem, indicating increased 5-HT turnover in those areas. After 2 and 4 h rebound sleep, the 5-HIAA/5-HT ratio was similar to that in controls. We conclude that a short SD increases 5-HT turnover in the rat brain for the duration of SD only.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9189895     DOI： 10.1097/00001756-199705060-00006

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  Chronic REM Sleep Restriction in Juvenile Male Rats Induces Anxiety-Like Behavior and Alters Monoamine Systems in the Amygdala and Hippocampus.

Authors:  Janaína da Silva Rocha-Lopes; Ricardo Borges Machado; Deborah Suchecki
Journal:  Mol Neurobiol       Date:  2017-04-28       Impact factor: 5.590

Review 2.  Sleep-mediated regulation of reward circuits: implications in substance use disorders.

Authors:  Rong Guo; Dylan Thomas Vaughan; Ana Lourdes Almeida Rojo; Yanhua H Huang
Journal:  Neuropsychopharmacology       Date:  2022-06-16       Impact factor: 7.853

Review 3.  Modulating role of serotonergic signaling in sleep and memory.

Authors:  Salar Vaseghi; Shirin Arjmandi-Rad; Maliheh Eskandari; Mahshid Ebrahimnejad; Gita Kholghi; Mohammad-Reza Zarrindast
Journal:  Pharmacol Rep       Date:  2021-11-06       Impact factor: 3.024

4.  Serotonin turnover in discrete regions of young rat brain after 24 h REM sleep deprivation.

Authors:  M Senthilvelan; R Ravindran; J Samson; R Shella Devi
Journal:  Neurochem Res       Date:  2006-01       Impact factor: 3.996

5.  REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy.

Authors:  Maira J Maturana; Cláudia Pudell; Adriano D S Targa; Laís S Rodrigues; Ana Carolina D Noseda; Mariana H Fortes; Patrícia Dos Santos; Cláudio Da Cunha; Sílvio M Zanata; Anete C Ferraz; Marcelo M S Lima
Journal:  Mol Neurobiol       Date:  2014-05-15       Impact factor: 5.590

6.  Sleep restriction acutely impairs glucose tolerance in rats.

Authors:  Pawan K Jha; Ewout Foppen; Andries Kalsbeek; Etienne Challet
Journal:  Physiol Rep       Date:  2016-06

7.  Associations Between a Polymorphism in the Rat 5-HT1A Receptor Gene Promoter Region (rs198585630) and Cognitive Alterations Induced by Microwave Exposure.

Authors:  Haijuan Li; Yu Gao; Yong Zou; Simo Qiao; Weijia Zhi; Lizhen Ma; Xinping Xu; Xuelong Zhao; Junhua Zhang; Lifeng Wang; Xiangjun Hu
Journal:  Front Public Health       Date:  2022-02-17
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.