UNLABELLED: The ability of 99mTc-pertechnetate/sestamibi subtraction, double-phase 99mTc-sestamibi and 99mTc-sestamibi SPECT imaging to localize abnormal parathyroid tissue was compared. METHODS: Fifty-five consecutive patients had parathyroid imaging before surgery for hyperparathyroidism. Imaging consisted of 99mTc-pertechnetate pinhole images of the neck followed by 99mTc-sestamibi pinhole images of the neck and parallel-hole images of the neck and chest (early images). Within 2.5-4.0 hr later pinhole images of the neck, parallel-hole and SPECT images of the neck and chest were obtained (late images). Nodular foci of increased sestamibi activity were considered abnormal. RESULTS: The sensitivity for abnormal parathyroid glands by visual comparison of early images and pertechnetate images was 72%-75%, late images and pertechnetate images was 73%-78% and double-phase (early and late) sestamibi images was 62%-65%; computer subtraction of pertechnetate from early images was 71%-74%; and SPECT imaging was 79%. The sensitivity for parathyroid adenomas was 89%-98%, while the sensitivity for hyperplastic parathyroid glands was only 47%-58%. CONCLUSION: Late imaging, computer subtraction and SPECT may not be necessary since they provided only marginal improvements on visual comparison of early sestamibi with pertechnetate images. Double-phase sestamibi imaging was less sensitive, so baseline thyroid imaging with pertechnetate is recommended.
UNLABELLED: The ability of 99mTc-pertechnetate/sestamibi subtraction, double-phase 99mTc-sestamibi and 99mTc-sestamibi SPECT imaging to localize abnormal parathyroid tissue was compared. METHODS: Fifty-five consecutive patients had parathyroid imaging before surgery for hyperparathyroidism. Imaging consisted of 99mTc-pertechnetate pinhole images of the neck followed by 99mTc-sestamibi pinhole images of the neck and parallel-hole images of the neck and chest (early images). Within 2.5-4.0 hr later pinhole images of the neck, parallel-hole and SPECT images of the neck and chest were obtained (late images). Nodular foci of increased sestamibi activity were considered abnormal. RESULTS: The sensitivity for abnormal parathyroid glands by visual comparison of early images and pertechnetate images was 72%-75%, late images and pertechnetate images was 73%-78% and double-phase (early and late) sestamibi images was 62%-65%; computer subtraction of pertechnetate from early images was 71%-74%; and SPECT imaging was 79%. The sensitivity for parathyroid adenomas was 89%-98%, while the sensitivity for hyperplastic parathyroid glands was only 47%-58%. CONCLUSION: Late imaging, computer subtraction and SPECT may not be necessary since they provided only marginal improvements on visual comparison of early sestamibi with pertechnetate images. Double-phase sestamibi imaging was less sensitive, so baseline thyroid imaging with pertechnetate is recommended.
Authors: Jaber S Abbas; Suzan I Hashem; Walid G Faraj; Mohammad J Khalifeh; Mukbil H Horani; Ibrahim S Salti Journal: World J Surg Date: 2006-01 Impact factor: 3.352
Authors: Tuan H Pham; Sylvester Sterioff; Brian P Mullan; Gregory A Wiseman; Thomas J Sebo; Clive S Grant Journal: World J Surg Date: 2006-03 Impact factor: 3.352
Authors: G Akbaba; D Berker; S Isik; Y Aydin; D Ciliz; I Peksoy; U Ozuguz; Y A Tutuncu; S Guler Journal: J Endocrinol Invest Date: 2011-05-27 Impact factor: 4.256
Authors: Thanseer N T K Padinhare-Keloth; Sanjay K Bhadada; Ashwani Sood; Rajender Kumar; Arunanshu Behera; Bishan D Radotra; Bhagwant R Mittal Journal: Nucl Med Mol Imaging Date: 2016-09-20
Authors: Martin Gotthardt; Bodo Lohmann; Thomas M Behr; Artur Bauhofer; Christiane Franzius; Meike L Schipper; Maria Wagner; Helmut Höffken; Helmut Sitter; Matthias Rothmund; Klaus Joseph; Christoph Nies Journal: World J Surg Date: 2003-11-26 Impact factor: 3.352