Literature DB >> 9188536

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.

O Pleskoff1, C Tréboute, A Brelot, N Heveker, M Seman, M Alizon.   

Abstract

The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.

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Year:  1997        PMID： 9188536     DOI： 10.1126/science.276.5320.1874

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  105 in total

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3.  Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?

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5.  Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor.

Authors:  B Labrosse; C Treboute; A Brelot; M Alizon
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

6.  Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.

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7.  Comparative sequence analysis of US28 gene of human cytomegalovirus strains isolated from HIV-positive patients.

Authors:  Anne Goffard; Elyanne Gault; Flore Rozenberg; Nicole Moret; Didier Hober; Paul Dény
Journal:  Virus Genes       Date:  2006-10       Impact factor: 2.332

8.  Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice.

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9.  Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion.

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10.  The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4.

Authors:  Kathleen L Arnolds; Angela P Lares; Juliet V Spencer
Journal:  Virology       Date:  2013-03-13       Impact factor: 3.616
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