Literature DB >> 9187648

X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.

C Eigenbrot, N Gerber.   

Abstract

The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.

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Year:  1997        PMID： 9187648     DOI： 10.1038/nsb0697-435

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  23 in total

1.  Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.

Authors:  Thomas B Thompson; Teresa K Woodruff; Theodore S Jardetzky
Journal:  EMBO J       Date:  2003-04-01       Impact factor: 11.598

2.  Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.

Authors:  Vaclav Veverka; Alistair J Henry; Patrick M Slocombe; Andrew Ventom; Barbara Mulloy; Frederick W Muskett; Mariusz Muzylak; Kevin Greenslade; Adrian Moore; Li Zhang; Jianhua Gong; Xueming Qian; Chris Paszty; Richard J Taylor; Martyn K Robinson; Mark D Carr
Journal:  J Biol Chem       Date:  2009-02-10       Impact factor: 5.157

3.  Investigating the Role of Artemin Glycosylation.

Authors:  Qiu Danwen; Christian Code; Chao Quan; Bang-Jin Gong; Joseph Arndt; Blake Pepinsky; Kasper D Rand; Damian Houde
Journal:  Pharm Res       Date:  2016-02-23       Impact factor: 4.200

Review 4.  Defining and designing polymers and hydrogels for neural tissue engineering.

Authors:  Emily R Aurand; Kyle J Lampe; Kimberly B Bjugstad
Journal:  Neurosci Res       Date:  2011-12-17       Impact factor: 3.304

5.  The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding.

Authors:  Ivan Alfano; Parvez Vora; Rosemary S Mummery; Barbara Mulloy; Christopher C Rider
Journal:  Biochem J       Date:  2007-05-15       Impact factor: 3.857

6.  Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons.

Authors:  K Krieglstein; P Henheik; L Farkas; J Jaszai; D Galter; K Krohn; K Unsicker
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

7.  Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.

Authors:  B S Schmutzler; S Roy; C M Hingtgen
Journal:  Neuroscience       Date:  2009-03-11       Impact factor: 3.590

8.  The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.

Authors:  Vimal Parkash; Veli-Matti Leppänen; Heidi Virtanen; Jaana M Jurvansuu; Maxim M Bespalov; Yulia A Sidorova; Pia Runeberg-Roos; Mart Saarma; Adrian Goldman
Journal:  J Biol Chem       Date:  2008-10-08       Impact factor: 5.157

9.  Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling.

Authors:  Vimal Parkash; Adrian Goldman
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-05-23

10.  Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.

Authors:  Jenny Sandmark; Göran Dahl; Linda Öster; Bingze Xu; Patrik Johansson; Tomas Akerud; Anna Aagaard; Pia Davidsson; Janna M Bigalke; Maria Sörhede Winzell; G Jonah Rainey; Robert G Roth
Journal:  J Biol Chem       Date:  2018-02-02       Impact factor: 5.157
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