Literature DB >> 9187208

A paradoxical effect of bronchodilators.

E Maury1, V Ioos, B Lepecq, B Guidet, G Offenstadt.   

Abstract

Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.

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Year:  1997        PMID: 9187208     DOI: 10.1378/chest.111.6.1766

Source DB:  PubMed          Journal:  Chest        ISSN: 0012-3692            Impact factor:   9.410


  4 in total

1.  Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.

Authors:  G J Rodrigo; C Rodrigo
Journal:  Emerg Med J       Date:  2005-06       Impact factor: 2.740

2.  Treating acute asthma--salbutamol may not always be the right answer.

Authors:  Sharon Sturney; Jay Suntharalingam
Journal:  Clin Med (Lond)       Date:  2012-04       Impact factor: 2.659

3.  Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Authors:  Joseph Vamecq; Karine Mention-Mulliez; Francis Leclerc; Dries Dobbelaere
Journal:  Pharmaceuticals (Basel)       Date:  2015-09-25

4.  Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis.

Authors:  Alina G Liedtke; Sebastiano A G Lava; Gregorio P Milani; Carlo Agostoni; Viola Gilardi; Mario G Bianchetti; Giorgio Treglia; Pietro B Faré
Journal:  J Clin Med       Date:  2019-12-27       Impact factor: 4.241

  4 in total

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