| Literature DB >> 9186790 |
S Claes1, P Raeymaekers, M Van den Broeck, S Diependaele, A De bruyn, G Verheyen, V Wils, A Boogaerts, A Tanghe, J Godderis, C Van Broeckhoven, J J Cassiman.
Abstract
The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.Entities:
Mesh：
Year: 1997 PMID： 9186790 DOI： 10.1016/s0165-0327(97)01429-8
Source DB: PubMed Journal: J Affect Disord ISSN： 0165-0327 Impact factor: 4.839