Literature DB >> 9185866

Alphavirus expression vectors and their use as recombinant vaccines: a minireview.

I Tubulekas1, P Berglund, M Fleeton, P Liljeström.   

Abstract

Alphavirus vectors have become widely used in basic research to study the structure and function of proteins and for protein production purposes. Development of a variety of vectors has made it possible to deliver foreign sequences as naked RNA or DNA, or as suicide virus particles produced using helper vector strategies. Preliminary reports also suggest that these vectors may be useful for in vivo applications where transient, high-level protein expression is desired, such as recombinant vaccines. The initial studies have already shown that alphavirus vaccines can induce strong humoral and cellular immune responses with good immunological memory and protective effects.

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Year:  1997        PMID： 9185866     DOI： 10.1016/s0378-1119(96)00679-8

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

1.  Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.

Authors:  I Frolov; E Agapov; T A Hoffman; B M Prágai; M Lippa; S Schlesinger; C M Rice
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor.

Authors:  C Hundt; J M Peyrin; S Haïk; S Gauczynski; C Leucht; R Rieger; M L Riley; J P Deslys; D Dormont; C I Lasmézas; S Weiss
Journal:  EMBO J       Date:  2001-11-01       Impact factor: 11.598

3.  Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity.

Authors:  Mark A Brockman; David M Knipe
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

4.  MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells.

Authors:  Margaret Chen; Christina Barnfield; Tanja I Näslund; Marina N Fleeton; Peter Liljeström
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

5.  Type I Interferons are essential for the efficacy of replicase-based DNA vaccines.

Authors:  Wolfgang W Leitner; Elke S Bergmann-Leitner; Leroy N Hwang; Nicholas P Restifo
Journal:  Vaccine       Date:  2006-05-06       Impact factor: 3.641

6.  A novel self-replicating chimeric lentivirus-like particle.

Authors:  Christy K Jurgens; Kelly R Young; Victoria J Madden; Philip R Johnson; Robert E Johnston
Journal:  J Virol       Date:  2011-10-19       Impact factor: 5.103

7.  Systemic, mucosal, and heterotypic immune induction in mice inoculated with Venezuelan equine encephalitis replicons expressing Norwalk virus-like particles.

Authors:  Patrick R Harrington; Boyd Yount; Robert E Johnston; Nancy Davis; Christine Moe; Ralph S Baric
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

8.  The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein.

Authors:  S Gauczynski; J M Peyrin; S Haïk; C Leucht; C Hundt; R Rieger; S Krasemann; J P Deslys; D Dormont; C I Lasmézas; S Weiss
Journal:  EMBO J       Date:  2001-11-01       Impact factor: 11.598

Review 9.  DNA and RNA-based vaccines: principles, progress and prospects.

Authors:  W W Leitner; H Ying; N P Restifo
Journal:  Vaccine       Date:  1999-12-10       Impact factor: 3.641

10.  Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein.

Authors:  John M Thomas; William B Klimstra; Kate D Ryman; Hans W Heidner
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103
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