AIMS: Positron emission tomographic imaging is known to be a reliable indicator of viable myocardium in chronic heart disease. Its value in acute myocardial infarction has not been studied extensively. METHODS AND RESULTS: Sixty-two patients receiving thrombolytic therapy were studied. Myocardial tissue flow and metabolism were measured at 5 days and 3 months. Recovery of left ventricular function was investigated with echocardiography or radionuclide ventriculography. In eight patients, normal flow was found in the infarct area at 5 days with no significant changes in flow, metabolism or function over the next 3 months. In 54 patients, impaired regional myocardial blood flow in the infarct zone was observed at 5 days. In 39 patients, there was a matching positron emission tomographic pattern, while in 15 the pattern was mismatched. None of the patients with a TIMI flow grade < 3 revealed recovery of left ventricular function. In seven out of 11 patients with TIMI 3 flow and a mismatching pattern, additional angioplasty was performed with functional improvement in six. CONCLUSIONS: Recovery of ventricular function is exclusively found in patients with a TIMI flow grade 3. Patients with a positron emission tomographic mismatching pattern reveal functional recovery only after subsequent angioplasty.
AIMS: Positron emission tomographic imaging is known to be a reliable indicator of viable myocardium in chronic heart disease. Its value in acute myocardial infarction has not been studied extensively. METHODS AND RESULTS: Sixty-two patients receiving thrombolytic therapy were studied. Myocardial tissue flow and metabolism were measured at 5 days and 3 months. Recovery of left ventricular function was investigated with echocardiography or radionuclide ventriculography. In eight patients, normal flow was found in the infarct area at 5 days with no significant changes in flow, metabolism or function over the next 3 months. In 54 patients, impaired regional myocardial blood flow in the infarct zone was observed at 5 days. In 39 patients, there was a matching positron emission tomographic pattern, while in 15 the pattern was mismatched. None of the patients with a TIMI flow grade < 3 revealed recovery of left ventricular function. In seven out of 11 patients with TIMI 3 flow and a mismatching pattern, additional angioplasty was performed with functional improvement in six. CONCLUSIONS: Recovery of ventricular function is exclusively found in patients with a TIMI flow grade 3. Patients with a positron emission tomographic mismatching pattern reveal functional recovery only after subsequent angioplasty.
Authors: Heinrich R Schelbert; Robert Beanlands; Frank Bengel; Juhani Knuuti; Marcelo Dicarli; Josef Machac; Randolph Patterson Journal: J Nucl Cardiol Date: 2003 Sep-Oct Impact factor: 5.952
Authors: Marcus Vinicius Simões; Oswaldo César de Almeida-Filho; Antonio Osvaldo Pintya; Alexandre Baldini de Figueiredo; Cleide Marques Antloga; Fernando Vilela Salis; Nadia de Paula Batista; Moysés de Oliveira Lima-Filho; Benedito Carlos Maciel; José Antonio Marin-Neto Journal: J Nucl Cardiol Date: 2002 May-Jun Impact factor: 5.952
Authors: Josef Machac; Stephen L Bacharach; Timothy M Bateman; Jeroen J Bax; Robert Beanlands; Frank Bengel; Steven R Bergmann; Richard C Brunken; James Case; Dominique Delbeke; Marcelo F DiCarli; Ernest V Garcia; Richard A Goldstein; Robert J Gropler; Mark Travin; Randolph Patterson; Heinrich R Schelbert Journal: J Nucl Cardiol Date: 2006-11 Impact factor: 3.872