Literature DB >> 9183549

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.

H Kühn1, L Chan.   

Abstract

Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.

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Year:  1997        PMID： 9183549     DOI： 10.1097/00041433-199704000-00009

Source DB:  PubMed          Journal:  Curr Opin Lipidol        ISSN： 0957-9672            Impact factor:   4.776


  16 in total

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8.  Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

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