Literature DB >> 9183546

Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?

P Arner1.   

Abstract

Familial combined hyperlipidaemia is a common cause of coronary heart disease. Its aetiology is heterogeneous. The genetic and metabolic basis of the disorder has not yet been defined. This review discusses the putative role of adipose tissue in the pathogenesis of familial combined hyperlipidaemia. It is possible that mutations in genes regulating the turnover of lipids in fat cells are involved in the aetiology.

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Year:  1997        PMID： 9183546     DOI： 10.1097/00041433-199704000-00006

Source DB:  PubMed          Journal:  Curr Opin Lipidol        ISSN： 0957-9672            Impact factor:   4.776


  13 in total

Review 1.  Metabolic pathogenesis of familial combined hyperlipidaemia with emphasis on insulin resistance, adipose tissue metabolism and free fatty acids.

Authors:  Jacqueline de Graaf; Mario J Veerkamp; Anton F H Stalenhoef
Journal:  J R Soc Med       Date:  2002       Impact factor: 5.344

2.  Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.

Authors:  P Pajukanta; J D Terwilliger; M Perola; T Hiekkalinna; I Nuotio; P Ellonen; M Parkkonen; J Hartiala; K Ylitalo; J Pihlajamäki; K Porkka; M Laakso; J Viikari; C Ehnholm; M R Taskinen; L Peltonen
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

3.  Dynamics of human adipose lipid turnover in health and metabolic disease.

Authors:  Peter Arner; Samuel Bernard; Mehran Salehpour; Göran Possnert; Jakob Liebl; Peter Steier; Bruce A Buchholz; Mats Eriksson; Erik Arner; Hans Hauner; Thomas Skurk; Mikael Rydén; Keith N Frayn; Kirsty L Spalding
Journal:  Nature       Date:  2011-09-25       Impact factor: 49.962

4.  ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction.

Authors:  Hao Wei; Elizabeth J Tarling; Timothy S McMillen; Chongren Tang; Renée C LeBoeuf
Journal:  J Lipid Res       Date:  2015-10-21       Impact factor: 5.922

5.  Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue.

Authors:  Simon Bissonnette; Huda Salem; Hanny Wassef; Nathalie Saint-Pierre; Annie Tardif; Alexis Baass; Robert Dufour; May Faraj
Journal:  J Lipid Res       Date:  2013-02-17       Impact factor: 5.922

6.  Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice.

Authors:  Kimberly A Edgel; Timothy S McMillen; Hao Wei; Nathalie Pamir; Barbara A Houston; Mark T Caldwell; Phuong-Oanh T Mai; John F Oram; Chongren Tang; Renée C Leboeuf
Journal:  Biochim Biophys Acta       Date:  2011-12-10

7.  A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.

Authors:  Christopher L Plaisier; Steve Horvath; Adriana Huertas-Vazquez; Ivette Cruz-Bautista; Miguel F Herrera; Teresa Tusie-Luna; Carlos Aguilar-Salinas; Päivi Pajukanta
Journal:  PLoS Genet       Date:  2009-09-11       Impact factor: 5.917

Review 8.  Recent advances in molecular genetics of cardiovascular disorders. Implications for atherosclerosis and diseases of cellular lipid metabolism.

Authors:  G Schmitz; C Aslanidis; K J Lackner
Journal:  Pathol Oncol Res       Date:  1998       Impact factor: 3.201

Review 9.  Genetics of familial combined hyperlipidemia.

Authors:  P Pajukanta; K V Porkka
Journal:  Curr Atheroscler Rep       Date:  1999-07       Impact factor: 5.967

10.  Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia.

Authors:  Keith Frayn; Samuel Bernard; Kirsty Spalding; Peter Arner
Journal:  J Am Heart Assoc       Date:  2012-12-19       Impact factor: 5.501
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