Literature DB >> 9183543

Chinese hamster ovary cell mutants affecting cholesterol metabolism.

T Y Chang1, M T Hasan, J Chin, C C Chang, D M Spillane, J Chen.   

Abstract

The approach of somatic cell and molecular genetics for the study of intracellular regulation of cholesterol metabolism has blossomed in recent years. This review lists all the Chinese hamster ovary cell mutants involved in cholesterol metabolism. In addition, it summarizes the characteristics of mutants involved in three different processes: (1) sequential cleavage of the membrane-bound sterol regulatory element-binding proteins; (2) cholesterol esterification; and (3) intracellular cholesterol transport from the lysosome/endosome.

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Year:  1997        PMID： 9183543     DOI： 10.1097/00041433-199704000-00003

Source DB:  PubMed          Journal:  Curr Opin Lipidol        ISSN： 0957-9672            Impact factor:   4.776


  4 in total

1.  Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography-mass spectrometry targeted metabonomic profiling.

Authors:  Priti Bahety; Thi Hai Van Nguyen; Yanjun Hong; Luqi Zhang; Eric Chun Yong Chan; Pui Lai Rachel Ee
Journal:  Eur J Nutr       Date:  2015-10-01       Impact factor: 5.614

2.  Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Authors:  H Shimano; I Shimomura; R E Hammer; J Herz; J L Goldstein; M S Brown; J D Horton
Journal:  J Clin Invest       Date:  1997-10-15       Impact factor: 14.808

3.  Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.

Authors:  Courtney Netherland; Douglas P Thewke
Journal:  Biochem Biophys Res Commun       Date:  2010-07-06       Impact factor: 3.575

4.  Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.

Authors:  H Watari; E J Blanchette-Mackie; N K Dwyer; J M Glick; S Patel; E B Neufeld; R O Brady; P G Pentchev; J F Strauss
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205
  4 in total

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