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Literature DB >> 9182691

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity.

Abstract

As a model to investigate the mechanism of caspase activation we have analysed the processing of pro-caspase-7 by serine proteases with varied specificities. The caspase-7 zymogen was rapidly activated by granzyme B and more slowly by subtilisin and cathepsin G, generating active enzymes with similar kinetic properties. Significantly, cathepsin G activated the zymogen by cleaving at a Gln-Ala bond, indicating that the canonical cleavage specificity at aspartic acid is not required for activation.

Entities: Chemical Gene

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Year: 1997 PMID： 9182691 PMCID： PMC1218439 DOI： 10.1042/bj3240361

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

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