| Literature DB >> 9180218 |
R Diaz1, P Sokoloff, K Fuxe.
Abstract
Glucocorticoids and dopamine (DA) may affect brain development and permanently programme central nervous system (CNS) responses. The ontogeny of the striatal glucocorticoid receptor (GR) mRNA and of DA D1, D2 and D3 receptor subtype mRNAs were, therefore, studied by means of in situ hybridization techniques. The expression of GR and the dopamine D3 receptor mRNAs but not of DA D1 and D2 receptor subtype mRNAs were observed in the striatal neuroepithelium during all prenatal stages studied (E14.5-E20.5). These results suggest that GR may directly influence striatal developmental processes, possibly involving the dopamine D3 receptor.Entities:
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Year: 1997 PMID: 9180218 DOI: 10.1016/s0304-3940(97)00316-9
Source DB: PubMed Journal: Neurosci Lett ISSN: 0304-3940 Impact factor: 3.046