| Literature DB >> 9180167 |
T L Yashina1, M O Favorov, Y E Khudyakov, H A Fields, O O Znoiko, T V Shkurko, T Bonafonte, J S Sevall, M S Agopian, J B Peter.
Abstract
The role of hepatitis G virus (HGV) infection in acute non-A-E hepatitis was investigated in adults with viral hepatitis. HGV RNA was present in 1 of 28 patients with non-A-E hepatitis but 9 of 22 with hepatitis C (P < .003). HGV RNA-positive patients (HGV-infected and HGV-hepatitis C virus [HCV]-coinfected) developed light-to-moderate jaundice. Clinical and biochemical features of HGV-positive and HCV-positive patients and patients with non-A, non-G hepatitis were similar. Three patients with HGV-HCV coinfection, tested within 18 months after disease onset, have remained HGV RNA-positive but have become HCV RNA-negative. Only 1 non-A-E hepatitis patient was confirmed as being infected with HGV alone, suggesting that HGV is not the main etiologic agent of non-A-E hepatitis. Although HGV RNA was significantly associated with hepatitis C, patients with mixed HCV-HGV infections did not demonstrate a more severe course of disease than did patients with HCV infection.Entities:
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Year: 1997 PMID： 9180167 DOI： 10.1086/516460
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226