Literature DB >> 9180080

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.

K Tanaka1, K Watase, T Manabe, K Yamada, M Watanabe, K Takahashi, H Iwama, T Nishikawa, N Ichihara, T Kikuchi, S Okuyama, N Kawashima, S Hori, M Takimoto, K Wada.   

Abstract

Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.

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Year:  1997        PMID： 9180080     DOI： 10.1126/science.276.5319.1699

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  548 in total

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Authors:  D J Slotboom; W N Konings; J S Lolkema
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7.  Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice.

Authors:  Moonnoh R Lee; Christina L Ruby; David J Hinton; Sun Choi; Chelsea A Adams; Na Young Kang; Doo-Sup Choi
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8.  Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy.

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Review 9.  Glutamate transporters in the biology of malignant gliomas.

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Authors:  Yun Zhou; Leonie F Waanders; Silvia Holmseth; Caiying Guo; Urs V Berger; Yuchuan Li; Anne-Catherine Lehre; Knut P Lehre; Niels C Danbolt
Journal:  J Biol Chem       Date:  2013-11-26       Impact factor: 5.157
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