| Literature DB >> 9178460 |
P M Norton1, J M Wells, H W Brown, A M Macpherson, R W Le Page.
Abstract
Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no requirement for either colonization or invasion of the mucosa. In addition secretory antibody responses in the lung and nasal tissues were elicited after i.n. inoculation in the presence of an adjuvant.Entities:
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Year: 1997 PMID： 9178460 DOI： 10.1016/s0264-410x(96)00241-1
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641