Literature DB >> 9177956

Sleep deprivation hastens the antidepressant action of fluoxetine.

F Benedetti1, B Barbini, A Lucca, E Campori, C Colombo, E Smeraldi.   

Abstract

Among ten bipolar depressed patients admitted to our psychiatric ward, five patients were treated with fluoxetine alone and five subjects were treated with fluoxetine in association with total sleep deprivation (TSD) in order to evaluate the effect of the interaction between the administration of the serotonergic antidepressant compound fluoxetine and repeated cycles of TSD. Patients treated with fluoxetine plus repeated TSD showed a faster amelioration of depressive symptomatology compared with the other group. We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication.

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Year:  1997        PMID: 9177956     DOI: 10.1007/BF02900200

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN: 0940-1334            Impact factor:   5.270


  35 in total

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  12 in total

Review 1.  Chronobiological Therapy for Mood Disorders.

Authors:  Sara Dallaspezia; Masahiro Suzuki; Francesco Benedetti
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10.  Pharmacological modulation of brain levels of glutamate and GABA in rats exposed to total sleep deprivation.

Authors:  Sahar Mohamed Kamal
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