Literature DB >> 9177499

Expression of multidrug resistance-associated protein gene in Ewing's sarcoma and malignant peripheral neuroectodermal tumor of bone.

Y Oda1, B Dockhorn-Dworniczak, H Jürgens, A Roessner.   

Abstract

The expression of multidrug resistance-associated protein (MRP) mRNA was examined in ten samples of Ewing's sarcoma of bone (ES) and in one nude mice transplantable ES and two malignant peripheral neuroectodermal tumor (MPNT) cell lines using an RT-PCR assay. MRP mRNA expression was recognized in eight of the ten clinical specimen and in all three cell lines. On the other hand, the expression of multidrug resistance gene (MDR1) was demonstrated in three of the ten clinical samples and all three cell lines. Our results may contribute to elucidation of the mechanism of anti-cancer-drug resistance in this tumor.

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Year:  1997        PMID： 9177499     DOI： 10.1007/BF01240323

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  12 in total

1.  Reverse transcriptase-polymerase chain reaction amplification of MDR1 gene expression in adult soft tissue sarcomas.

Authors:  Y Oda; R Schneider-Stock; J Ryś; A Gruchała; A Niezabitowski; A Roessner
Journal:  Diagn Mol Pathol       Date:  1996-06

2.  Surgical complications after preoperative irradiation of Ewing's sarcoma.

Authors:  A Hillmann; T Ozaki; C Rübe; C Hoffmann; A Schuck; S Blasius; A Haas; H Jürgens; W Winkelmann
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  [Molecular genetic detection of t(11;22)(q24;12) translocation in Ewing sarcoma and malignant peripheral neuroectodermal tumors].

Authors:  B Dockhorn-Dworniczak; K L Schäfer; R Dantcheva; S Blasius; F van Valen; S Burdach; W Winkelmann; H Jürgens; W Böcker
Journal:  Pathologe       Date:  1994-04       Impact factor: 1.011

4.  Expression of multidrug resistance-associated protein (MRP) in anaplastic carcinoma of the thyroid.

Authors:  I Sugawara; T Arai; T Yamashita; A Yoshida; A Masunaga; S Itoyama
Journal:  Cancer Lett       Date:  1994-07-29       Impact factor: 8.679

5.  Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma.

Authors:  S B Bordow; M Haber; J Madafiglio; B Cheung; G M Marshall; M D Norris
Journal:  Cancer Res       Date:  1994-10-01       Impact factor: 12.701

6.  Immunohistochemical detection of P-glycoprotein in Ewing's sarcoma and peripheral primitive neuroectodermal tumors before and after chemotherapy.

Authors:  Y M Hijazi; C A Axiotis; S Navarro; S M Steinberg; M E Horowitz; M Tsokos
Journal:  Am J Clin Pathol       Date:  1994-07       Impact factor: 2.493

7.  Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias.

Authors:  H Burger; K Nooter; G J Zaman; P Sonneveld; K E van Wingerden; R G Oostrum; G Stoter
Journal:  Leukemia       Date:  1994-06       Impact factor: 11.528

8.  Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas.

Authors:  Y Oda; R Schneider-Stock; J Ryś; A Gruchala; A Niezabitowski; A Roessner
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

9.  Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

Authors:  K E Noonan; C Beck; T A Holzmayer; J E Chin; J S Wunder; I L Andrulis; A F Gazdar; C L Willman; B Griffith; D D Von Hoff; I B Roninson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

10.  Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients.

Authors:  U Stein; V Wunderlich; W Haensch; P Schmidt-Peter
Journal:  Eur J Cancer       Date:  1993       Impact factor: 9.162
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  2 in total

1.  Exploration of Potential Ewing Sarcoma Drugs from FDA-Approved Pharmaceuticals through Computational Drug Repositioning, Pharmacogenomics, Molecular Docking, and MD Simulation Studies.

Authors:  Mubashir Hassan; Muhammad Yasir; Saba Shahzadi; Andrzej Kloczkowski
Journal:  ACS Omega       Date:  2022-06-01

2.  Membrane expression of MRP-1, but not MRP-1 splicing or Pgp expression, predicts survival in patients with ESFT.

Authors:  E Roundhill; S Burchill
Journal:  Br J Cancer       Date:  2013-06-25       Impact factor: 7.640
  2 in total

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