| Literature DB >> 9177463 |
C J Vennegoor1, H W Nijman, J W Drijfhout, L Vernie, R A Verstraeten, S von Mensdorff-Pouilly, J Hilgers, R H Verheijen, W M Kast, C J Melief, P Kenemans.
Abstract
Autoantibodies against complete p53 protein and 18-mer peptides of p53 in ovarian cancer patients and healthy women were examined. Sera from 9% (4/46) of ovarian cancer patients but none (0/51) of healthy women recognized complete p53 protein. The antibodies were mainly of the IgG1 isotype. Two patients had also IgG2 antibodies. Sera from 28% (13/46) of cancer patients and 21% (11/52) of healthy women contained either IgM, or IgM plus IgG2 antibodies against 18-mer p53 peptides. Screening against complete p53 protein instead of peptides seems necessary for identifying patients with tumor-related antibodies. IgG2 antibodies against p53 suggest p53-specific CD4+ T helper 1 cell activity in some of the ovarian cancer patients.Entities:
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Year: 1997 PMID： 9177463 DOI： 10.1016/s0304-3835(97)00168-7
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679