Literature DB >> 9177462

Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice.

G Sersa1, M Cemazar, V Menart, V Gaberc-Porekar, D Miklavcic.   

Abstract

With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment.

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Year:  1997        PMID： 9177462     DOI： 10.1016/s0304-3835(97)00170-5

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  13 in total

1.  The importance of electric field distribution for effective in vivo electroporation of tissues.

Authors:  D Miklavcic; K Beravs; D Semrov; M Cemazar; F Demsar; G Sersa
Journal:  Biophys J       Date:  1998-05       Impact factor: 4.033

Review 2.  Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment.

Authors:  Armando De Virgilio; Massimo Ralli; Lucia Longo; Patrizia Mancini; Giuseppe Attanasio; Francesca Atturo; Marco De Vincentiis; Antonio Greco
Journal:  Oncol Lett       Date:  2018-07-12       Impact factor: 2.967

Review 3.  Electroporation and Immunotherapy-Unleashing the Abscopal Effect.

Authors:  Tobias Freyberg Justesen; Adile Orhan; Hans Raskov; Christian Nolsoe; Ismail Gögenur
Journal:  Cancers (Basel)       Date:  2022-06-10       Impact factor: 6.575

4.  Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity.

Authors:  Ales Sedlar; Tanja Dolinsek; Bostjan Markelc; Lara Prosen; Simona Kranjc; Masa Bosnjak; Tanja Blagus; Maja Cemazar; Gregor Sersa
Journal:  Radiol Oncol       Date:  2012-11-09       Impact factor: 2.991

5.  Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy.

Authors:  M Cemazar; C S Parkins; A L Holder; D J Chaplin; G M Tozer; G Sersa
Journal:  Br J Cancer       Date:  2001-02       Impact factor: 7.640

Review 6.  Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer.

Authors:  Gregor Sersa; Justin Teissie; Maja Cemazar; Emanuela Signori; Urska Kamensek; Guillermo Marshall; Damijan Miklavcic
Journal:  Cancer Immunol Immunother       Date:  2015-06-12       Impact factor: 6.968

7.  Assessing a novel immuno-oncology-based combination therapy: Ipilimumab plus electrochemotherapy.

Authors:  Nicola Mozzillo; Ester Simeone; Lucia Benedetto; Marcello Curvietto; Diana Giannarelli; Giusy Gentilcore; Rosa Camerlingo; Mariaelena Capone; Gabriele Madonna; Lucia Festino; Corrado Caracò; Gianluca Di Monta; Ugo Marone; Massimiliano Di Marzo; Antonio M Grimaldi; Stefano Mori; Gennaro Ciliberto; Paolo A Ascierto
Journal:  Oncoimmunology       Date:  2015-05-22       Impact factor: 8.110

8.  Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.

Authors:  Maja Cemazar; Vesna Todorovic; Janez Scancar; Ursa Lampreht; Monika Stimac; Urska Kamensek; Simona Kranjc; Andrej Coer; Gregor Sersa
Journal:  Radiol Oncol       Date:  2015-03-03       Impact factor: 2.991

Review 9.  Electrochemotherapy: from the drawing board into medical practice.

Authors:  Damijan Miklavčič; Barbara Mali; Bor Kos; Richard Heller; Gregor Serša
Journal:  Biomed Eng Online       Date:  2014-03-12       Impact factor: 2.819

10.  Use of electrochemotherapy in a case of neck skin metastasis of oral squamous cell carcinoma: case report and considerations.

Authors:  Gian Franco Macri; Antonio Greco; Andrea Gallo; Massimo Fusconi; Caterina Marinelli; Marco de Vincentiis
Journal:  Head Neck       Date:  2014-02-27       Impact factor: 3.147
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