Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 TNF-alpha stimulates the biosynthesis of complement C3 and factor B by human umbilical cord vein endothelial cells.

Literature DB >> 9177453

TNF-alpha stimulates the biosynthesis of complement C3 and factor B by human umbilical cord vein endothelial cells.

Y Kawakami¹, Y Watanabe, M Yamaguchi, H Sakaguchi, I Kono, A Ueki.

Abstract

The human umbilical cord vein (HUVEC) endothelial cells synthesize and secrete complement components. We analyzed the regulation of biosynthesis of the third component of complement (C3) and factor B (Bf) by cytokines in endothelial cells. Production of C3 increased after stimulation with TNF-alpha or IL-1beta and that of Bf with TNF-alpha, TNF-beta and IFN-gamma. TNF-alpha was the most effective in stimulating the secretion of C3 and Bf or the expression of mRNA of C3 or Bf. Preincubation with TNF-alpha for at least 36 or 24 h was needed for the stimulation, respectively. TNF-alpha, together with IFN-gamma had synergistic effects and the release of C3 or Bf increased to about 40- and 26-fold higher than those in control cells after incubation with both cytokines.

Entities: Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9177453 DOI： 10.1016/s0304-3835(97)04737-x

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

Keyword Cloud
Cited

12 in total

1. Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms.

Authors: David J Kaczorowski; Amin Afrazi; Melanie J Scott; Joon H Kwak; Roop Gill; Rebecca D Edmonds; Yujian Liu; Jie Fan; Timothy R Billiar
Journal: J Leukoc Biol Date: 2010-04-22 Impact factor: 4.962

TNF-alpha stimulates the biosynthesis of complement C3 and factor B by human umbilical cord vein endothelial cells.

1. Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms.

2. Host chemokine and cytokine response in the endocervix within the first developmental cycle of Chlamydia muridarum.

3. Mammalian DNA is an endogenous danger signal that stimulates local synthesis and release of complement factor B.

4. Nonstructural Protein 1 of Variant PEDV Plays a Key Role in Escaping Replication Restriction by Complement C3.

Review 5. Biomarkers of obesity and subsequent cardiovascular events.

6. Aberrant activation of the complement system in renal grafts is mediated by cold storage.

7. Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts.

8. Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.

9. AICAR suppresses TNF-α-induced complement factor B in RPE cells.

10. The inflammatory effects of TNF-α and complement component 3 on coagulation.